Immunization status of Iranian military recruits against Bordetella pertussis infection (whooping cough).
Immunization status of Iranian military recruits against Bordetella pertussis infection (whooping cough).
复制标题
伊朗新兵的百日咳博德特氏菌感染（百日咳）免疫状况。
DOI：
10.3855/jidc.948
复制
发表时间：
2011
影响因子：
1.9
通讯作者：
Hamid Soheylipoor
中科院分区：
文献类型：
--
作者：
M. Izadi;S. Afsharpaiman;N. Jonaidi Jafari;R. Ranjbar;M. Gooya;Javad Robat Sarpooshi;A. Esfahani;Hamid Soheylipoor
介绍
由于抗生素耐药性增加和缺乏有效的疫苗，新兵容易感染呼吸道病原体。本研究的目的是确定在伊朗军事驻军的应征入伍者之间的百日咳博德特氏菌的免疫状态。
方法
研究人群包括424名年龄在18至21岁之间的应征入伍者。他们是从伊朗特赫拉的所有军营中采用整群分层抽样选出的。为了确定感染的血清阳性率，收集所有新兵的血液样本并储存在-20 °C下直至测定。所有血清样本进行筛选免疫球蛋白G（IgG）抗体百日咳杆菌毒素（PT）和使用酶联免疫吸附试验（ELISA）。
结果
B.新兵百日咳血清阳性率为60.6。仅55.0%的新兵对B疫苗接种记录知晓率低。儿童时期的百日咳在424名研究对象中，48名新兵（11.3%）有百日咳阳性史，这些新兵的血清阳性率为70.0%。在这些受试者中，61.7%的受试者被转诊至医生处接受治疗，其中仅39.6%的受试者接受了抗百日咳治疗。
结论
我们的研究表明，在德黑兰驻军的军事应征入伍者对百日咳没有血清免疫力，也证实了伊朗人口中这一高危亚群对百日咳感染相关疫苗接种和病史的认识不足。建议常规接种无细胞加强疫苗，特别是在18岁之前。
INTRODUCTION
Military recruits are susceptible to respiratory pathogens because of increased antibiotic resistance and the lack of an effective vaccine. The goal of the current study was to determine the immunological status of the Bordetella pertussis among conscripts in Iranian military garrisons.
METHODOLOGY
The study population consisted of 424 conscripts aged 18 to 21 years who enrolled for military service. They were selected using cluster stratified sampling from all military garrisons in Tehra, Iran. To determine the seroprevalence of infection, blood specimens from all recruits were collected and stored at - 20 °C until assayed. All serum samples were screened for immunoglobulin G (IgG) antibodies against Bordetella pertussis toxin (PT) and by using enzyme-linked immunosorbent assay (ELISA).
RESULTS
The overall prevalence of B. pertussis seropositivity in military recruits was 60.6. Only 55.0% of the recruits had low awareness about the record of vaccination against B. pertussis during childhood. Among 424 studied individuals, 48 recruits (11.3%) had a positive history of whooping cough; prevalence of seropositivity in these recruits was 70.0%. Among these subjects, 61.7% were referred to a physician for treatment and only 39.6% of them were administered anti-pertussis therapy.
CONCLUSIONS
Our study showed that military conscripts in Tehran garrisons were not serologically immune to pertussis and also confirmed the low awareness about vaccination and medical history related to pertussis infection in this high-risk subgroup of the Iranian population. Routine acellular booster vaccination, particularly before 18 years of age, is recommended.