Asperger's syndrome and cortical neuropathology
Asperger's syndrome and cortical neuropathology
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DOI：
10.1177/088307380201700211
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发表时间：
2002-02-01
影响因子：
1.9
通讯作者：
Roy, E
中科院分区：
文献类型：
--
作者：
Casanova, MF;Buxhoeveden, DP;Roy, E
伯格综合征的特征是社会交往受损，智力正常，语法和词汇方面的语言技能不足。这些症状在自然界中普遍存在，通常在儿童时期表现出来。尽管病情严重且长期存在。医学文献仍然稀少，没有提供任何关于可能的神经病理学基础的信息。本研究是一个病例报告的两名患者的伯格综合征。神经病理检查显示无退行性改变或胶质增生。通过计算机图像分析进行的更详细的评估表明，所检查的三个区域的微柱组织存在异常（9，21，22）（P = 0.032）。具体而言，微柱较小，其组成细胞比正常细胞更分散。最近有关于自闭症的类似神经病理学的报道，并对这些发现的独特性提出了质疑。微柱改变提供了一个可能的联系，感受野异常和一个有用的临床病理学相关的伯格综合征。
Asperger's disorder or syndrome is characterized by impaired social interaction, normal intelligence, and adequate language skills in the areas of grammar and vocabulary. The symptoms are pervasive in nature and usually manifested in childhood. Despite the gravity and chronicity of the condition. the medical literature remains sparse and offers no information about possible neuropathologic underpinnings. The present study is a case report on two patients with Asperger's syndrome. Neuropathologic examination revealed no degenerative changes or gliosis. A more detailed assessment with computerized image analysis indicated abnormalities in the minicolumnar organization of the three areas examined (9, 21, 22) (P =.032). Specifically, minicolumns were smaller, and their component cells were more dispersed than normal. A similar neuropathology has recently been reported for autism and disputes the uniqueness of these findings. The minicolumnar changes provide a possible link to receptive field abnormalities and a useful clinicopathologic correlate to Asperger's syndrome.