The viral infectivity factor (Vif) of HIV-1 unveiled.
The viral infectivity factor (Vif) of HIV-1 unveiled.
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DOI：
10.1016/j.molmed.2004.04.008
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发表时间：
2004-06
影响因子：
13.6
通讯作者：
K. Rose;M. Marin;S. Kozak;D. Kabat
中科院分区：
文献类型：
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作者：
K. Rose;M. Marin;S. Kozak;D. Kabat
HIV-1(HIV-1)的病毒感染性因子(VIF)对于有效的病毒复制是必不可少的，但直到最近还是个谜。这是由于其功能的复杂性和细胞特异性，以及研究其所需的相应的复杂系统。这些局限性已被克服，VIF功能已被迅速阐明，这对开发阻断其活性的药物具有重要意义。这些研究揭示了先天免疫系统的一种新成分APOBEC3G，它可以致命地高度突变包括HIV-1在内的逆转录病毒。对于HIV-1，病毒与APOBEC3G之间的竞争倾向于Vif入侵者，Vif与APOBEC3G结合，触发其多泛素化和快速降解，从而阻止其进入后代病毒子。
The viral infectivity factor (Vif) of HIV type-1 (HIV-1) is essential for efficient viral replication, yet was, until recently, enigmatic. This resulted from the complexity and cellular specificity of its function and the correspondingly complex systems that are required for its investigation. These limitations have been overcome and Vif function has been rapidly elucidated, with implications for the development of drugs to block its activity. These studies have revealed a novel component of the innate immune system, APOBEC3G, that lethally hypermutates retroviruses, including HIV-1. For HIV-1, the competition between the virus and APOBEC3G is tipped in favor of the invader by Vif, which binds to APOBEC3G and triggers its polyubiquitination and rapid degradation, thereby preventing its entry into progeny virions.