Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study
Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study
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DOI：
10.1016/s0926-6410(02)00066-6
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发表时间：
2002-06-01
期刊：
影响因子：
--
通讯作者：
Foxe, JJ
中科院分区：
文献类型：
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作者：
Molholm, S;Ritter, W;Foxe, JJ
来自多种感官的信息整合是感知和认知的基础，但大脑何时何地实现这一点尚不清楚。本研究在简单的反应时间（RT）任务中使用高密度事件相关电位（ERP）检查了皮质听觉-视觉相互作用的时间和地形。视觉和听觉刺激单独且同时呈现。将单独呈现时由听觉和视觉刺激引起的 ERP 进行求和（“总和”ERP），并与同时呈现时引发的 ERP（“同时”ERP）进行比较。 “同时”和“总和”ERP 之间的差异表明听觉-视觉 (AV) 神经反应相互作用。令人惊讶的是，早期的右顶枕 AV 相互作用与早期研究的结果一致 [J.认知。神经科学。 11（1999）473]。这种效应的开始时间（46 毫秒）基本上与视觉皮层处理的开始同时进行，如视觉 C1 分量的开始所指示，视觉 C1 分量被认为代表了最早的皮层视觉诱发电位。早期 AV 相互作用和 C1 的重合时间强烈表明 AV 相互作用可以影响早期视觉感觉处理。在感觉处理的时间过程中（刺激开始后最多 200 毫秒）发现了额外的 AV 相互作用。总而言之，头皮上的这种 AV 效应系统暗示了多感觉处理特有的活动以及“单感觉”活动的调节。同时呈现的刺激的 RT 明显快于单独呈现时的 RT 促进，这种 RT 促进不能通过概率求和来解释，正如违反“竞赛”模型所证明的那样，这提供了令人信服的证据，表明听觉-视觉神经相互作用引起了这种 RT 效应。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Integration of information from multiple senses is fundamental to perception and cognition, but when and where this is accomplished in the brain is not well understood. This Study examined the timing and topography of cortical auditory-visual interactions using high-density event-related potentials (ERPs) during a simple reaction-time (RT) task. Visual and auditory stimuli were presented alone and simultaneously. ERPs elicited by the auditory and visual stimuli when presented alone were summed ('sum' ERP) and compared to the ERP elicited when they were presented simultaneously ('simultaneous' ERP). Divergence between the 'simultaneous' and 'sum' ERP indicated auditory-visual (AV) neural response interactions. There was a surprisingly early right parieto-occipital AV interaction, consistent with the finding of an earlier study [J. Cogn. Neurosci. 11 (1999) 473]. The timing of onset of this effect (46 ms) was essentially simultaneous with the onset of visual cortical processing, as indexed by the onset of the visual C1 component, which is thought to represent the earliest cortical visual evoked potential. The coincident timing of the early AV interaction and C1 strongly suggests that AV interactions can affect early visual sensory processing. Additional AV interactions were found within the time course of sensory processing (up to 200 ms post stimulus onset). In total, this system of AV effects over the scalp was suggestive of both activity unique to multisensory processing, and the modulation of 'unisensory' activity. RTs to the stimuli when presented simultaneously were significantly faster than when they were presented alone, This RT facilitation could not be accounted for by probability summation, as evidenced by violation of the 'race' model, providing compelling evidence that auditory-visual neural interactions give rise to this RT effect. (C) 2002 Elsevier Science B.V. All rights reserved.