Adipokines in rheumatoid arthritis
Adipokines in rheumatoid arthritis
复制标题
DOI：
10.1186/s42358-018-0026-8
复制
发表时间：
2018-01-01
影响因子：
2.3
通讯作者：
Dichi, Isaias
中科院分区：
文献类型：
--
作者：
Fatel, Elis Carolina de Souza;Rosa, Flávia Troncon;Dichi, Isaias
类风湿性关节炎影响着全球数百万人，被认为是一种病因不明的慢性多系统疾病。一般来说，类风湿性关节炎治疗的主要目的是通过减轻疼痛、维持或改善功能能力、预防残疾来提高患者的生活质量。近年来，脂肪因子在类风湿性关节炎发病机制中的作用已经被讨论，但结果仍然是相互矛盾的。尽管一些研究结果表明脂肪因子在包括类风湿性关节炎在内的自身免疫性疾病的病理生理学中的意义，但它们在疾病进展机制中的作用尚不清楚。因此，鉴于类风湿性关节炎的高患病率和这种慢性致残性疾病造成的重要社会影响，本综述旨在描述关键脂肪因子(瘦素、抵抗素、内脂素和脂联素)与类风湿性关节炎的关系。
Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability. In recent years the role of adipokines in the pathogenesis of rheumatoid arthritis has been discussed but results are still conflicting. Although results from some studies have shown the implications of adipokines in the pathophysiology of autoimmune diseases, including rheumatoid arthritis, their role in the pathogenesis of disease progression is not clear. Thus, this review aimed to describe the association of key adipokines (leptin, resistin, visfatin and adiponectin) and rheumatoid arthritis, given the high prevalence of this disease and the important social impact caused by this chronic disabling disease.