The Asn505 mutation of c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity.
The Asn505 mutation of c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity.
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c-MPL 基因的 Asn505 突变会导致家族性原发性血小板增多症,由于强氨基酸极性,会诱导 c-Mpl 蛋白自主同二聚化。
DOI:
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发表时间:
2009
期刊:
影响因子:
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通讯作者:
Ueda R
中科院分区:
文献类型:
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作者:
Ding J;Komatsu H;Iida S;Yano H;Kusumoto S;Inagaki A;Mori F;Ri M;Ito A;Wakita A;Ishida T;Nitta M;Ueda R