Chronic kidney disease is associated with incident cognitive impairment in the elderly: the INVADE study
Chronic kidney disease is associated with incident cognitive impairment in the elderly: the INVADE study
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DOI：
10.1093/ndt/gfp230
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发表时间：
2009-10-01
影响因子：
6.1
通讯作者：
Bickel, Horst
中科院分区：
文献类型：
--
作者：
Etgen, Thorleif;Sander, Dirk;Bickel, Horst
背景资料。关于肾功能下降和认知损害之间的关系，目前存在有限的数据。埃伯斯伯格社区脑血管疾病和痴呆症干预项目(INVADE)共有3679名参与者组成了这项基于社区的队列研究。肾功能的测量使用Cockcroft-Gault方程进行估计，并将其分为正常、轻度和中度至重度肾功能受损(肌酐清除量=60，45-59和
Background. Limited data exist regarding the relationship between decreased renal function and cognitive impairment.Methods. A total of 3679 participants of the Intervention Project on Cerebrovascular Diseases and Dementia in the Community of Ebersberg (INVADE) composed the community-based cohort study. Measures of renal function were estimated using the Cockcroft-Gault equation and divided into normal, mild and moderate-to-severe impaired renal function (creatinine clearance >= 60, 45-59 and