Alleles of the rat T-cell receptor beta chain gene complex.
Alleles of the rat T-cell receptor beta chain gene complex.
复制标题
大鼠 T 细胞受体 β 链基因复合体的等位基因。
DOI：
10.1007/bf00189895
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发表时间：
1992
期刊：
影响因子：
3.2
通讯作者：
Gutman,GA
中科院分区：
文献类型：
--
作者：
Blankenhorn,EP;Smith,PD;Williams,CB;Gutman,GA
Inbred rat strains provide a rich source of genetic diversity in immunologically relevant gense. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor Cβ1 chain, by Southern blots and nucleic acid sequencing. TheCb1gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3′ to the coding region. TheCb1alleles are one part of largerTcrbhaplotypes, containing Vβ, Dβ, and Jβ elements; completeCb1genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.
