Primary central nervous system lymphoma in a child with acute B-cell lymphoblastic leukaemia: consecutive Epstein-Barr virus-related malignancies.

Primary central nervous system lymphoma in a child with acute B-cell lymphoblastic leukaemia: consecutive Epstein-Barr virus-related malignancies.
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患有急性 B 细胞淋巴细胞白血病的儿童的原发性中枢神经系统淋巴瘤:连续的 Epstein-Barr 病毒相关恶性肿瘤。

DOI:
10.1046/j.1365-2141.1998.00709.x
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发表时间:
1998
影响因子:
6.5
通讯作者:
Slobod,KS
Slobod,KS
中科院分区:
医学2区
文献类型:
--
作者:
Buckingham,SC;Benaim,E;Sandlund,JT;Gan,YJ;Freiden,PJ;Behm,FG;Ribeiro,RC;Sixbey,JW;Slobod,KS

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原发性中枢神经系统淋巴瘤(PCNSL),免疫功能低下的艾滋病患者中观察到的,尚未报告在化疗急性淋巴细胞白血病(ALL)。我们报告一例发生于一名接受强化多药化疗治疗B细胞ALL的儿童的PCNSL。原位杂交研究表明,两种肿瘤中均存在巴尔病毒基因组,表明两种疾病之间可能存在联系。PCNSL对保守治疗的临床反应突出了准确诊断此类EBV相关疾病的重要性,尤其是在免疫受损可以逆转的患者中。
Primary central nervous system lymphoma (PCNSL), observed among immunocompromised AIDS patients, has not been reported during chemotherapy for acute lymphoblastic leukaemia (ALL). We report a case of PCNSL occurring in a child receiving intensive multiagent chemotherapy for B‐cell ALL.In situhybridization studies demonstrated Epstein‐Barr virus genome in both tumours, suggesting a possible link between the two diseases. The clinical response of the PCNSL to conservative therapy highlights the importance of accurately diagnosing such EBV‐related disorders, especially in patients where immune compromise can be reversed.
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