Impact of sertraline on serum concentration of CRP in hemodialysis patients with depression.
Impact of sertraline on serum concentration of CRP in hemodialysis patients with depression.
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DOI：
10.15171/jrip.2017.12
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发表时间：
2017
影响因子：
0.7
通讯作者：
Nikbakht H
中科院分区：
文献类型：
--
作者：
Zahed NS;Sharifi M;Karimi M;Nikbakht H
导读：抑郁症是血液透析（HD）患者中最普遍的心理问题。据报道，炎症因子在抑郁症的发病机制中起着重要作用。在慢性肾脏疾病（CKD）患者中，抑郁与炎症因子之间存在关联。舍曲林是一种选择性血清素再摄取抑制剂（SSRI）抗抑郁药，可降低抑郁症患者血清炎症因子水平。目的：本研究旨在评价舍曲林对抑郁症血液透析（HD）患者血清c反应蛋白（CRP）、血红蛋白和白蛋白的影响。患者和方法：在一项临床试验中，35名抑郁症HD患者和CRP bbb50被分配接受舍曲林治疗12周。采用贝克抑郁量表第二版（BDI-II）评估患者的抑郁程度，在基线和研究的第4、8、12周测量患者的生化参数（血红蛋白、血清白蛋白等）和CRP水平。观察舍曲林治疗前后12周BDI-II评分。结果：舍曲林可显著改善HD患者的抑郁症状。在研究结束时，BDI-II评分与基线相比有显著变化（P=0.001），血清CRP水平在研究开始的第12周显著下降（P=0.001）。而血红蛋白浓度、血清白蛋白浓度及体重变化不显著（P=0.995、P=0.328）。结论：舍曲林可显著降低HD患者的CRP水平，可能是一种有希望的减轻全身炎症和治疗抑郁症的策略。
Introduction: Depression is the most prevalent psychological problem among hemodialysis (HD) patients. Inflammatory factors have been reported to play an important role in the pathogenesis of depression. The association between depression and inflammatory factors was established in chronic kidney disease (CKD) patients. Sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant, decreases serum levels of inflammatory factors in patients with depression. Objectives: This study was designed to assess the effect of sertraline on serum concentration of C-reactive protein (CRP), hemoglobin and albumin of depressed hemodialysis (HD) patients. Patients and Methods: During a clinical trail, 35 depressed HD patients, and CRP >5 were allocated to receive sertraline for 12 weeks. Patients’ depression was assessed using Beck depression inventory second edition (BDI-II) biochemical parameters (hemoglobin, serum albumin, etc) and CRP levels were measured at baseline and at weeks 4, 8 and 12 of the study. BDI-II score was evaluated before and after 12 weeks treatment with sertraline. Results: Sertraline significantly improved depression symptoms in HD patients. At the end of the study, BDI-II scores significantly changed from baseline (P=0.001) and serum levels of CRP significantly decreased at week 12 of initiation of the study (P=0.001). However, the concentration of hemoglobin and serum albumin concentration and weight was not changed significantly (P=0.995 and P=0.328, respectively). Conclusion: Sertraline significantly decreases CRP levels and can be a promising strategy to reduce the systemic inflammation and to treat depression in HD patients.