The c-Rel Transcription Factor in Development and Disease.
The c-Rel Transcription Factor in Development and Disease.
复制标题
DOI：
10.1177/1947601911421925
复制
发表时间：
2011-07-01
期刊：
影响因子：
--
通讯作者：
Gerondakis, Steve
中科院分区：
文献类型：
--
作者：
Gilmore, Thomas D;Gerondakis, Steve
c-Rel是核因子κ B（NF-κ B）转录因子家族的成员。与在多种细胞类型中表达的其他NF-κ B蛋白不同，主要在B和T细胞中发现高水平的c-Rel表达，其中许多c-Rel靶基因参与淋巴样细胞生长和存活。除了c-Rel在哺乳动物B和T细胞功能中起主要作用之外，人c-rel基因（REL）是某些自身免疫性疾病如关节炎、银屑病和乳糜泻的易感性基因座。REL基因座也经常改变（扩增、突变、重排），并且REL的表达在多种B和T细胞恶性肿瘤中增加，并且在较小程度上在其它癌症类型中增加。因此，调节REL活性的药剂可能对某些人类癌症和慢性炎性疾病具有治疗益处。
c-Rel is a member of the nuclear factor kappaB (NF-kappaB) transcription factor family. Unlike other NF-kappaB proteins that are expressed in a variety of cell types, high levels of c-Rel expression are found primarily in B and T cells, with many c-Rel target genes involved in lymphoid cell growth and survival. In addition to c-Rel playing a major role in mammalian B and T cell function, the human c-rel gene (REL) is a susceptibility locus for certain autoimmune diseases such as arthritis, psoriasis, and celiac disease. The REL locus is also frequently altered (amplified, mutated, rearranged), and expression of REL is increased in a variety of B and T cell malignancies and, to a lesser extent, in other cancer types. Thus, agents that modulate REL activity may have therapeutic benefits for certain human cancers and chronic inflammatory diseases.