A steroid-conjugated magnetic resonance probe enhances contrast in progesterone receptor expressing organs and tumors in vivo.
A steroid-conjugated magnetic resonance probe enhances contrast in progesterone receptor expressing organs and tumors in vivo.
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DOI：
10.1021/mp200219e
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发表时间：
2011-08-01
影响因子：
4.9
通讯作者：
Burdette JE
中科院分区：
文献类型：
--
作者：
Sukerkar PA;MacRenaris KW;Meade TJ;Burdette JE
孕激素受体（PR）是子宫内膜异位症、乳腺癌、卵巢癌和子宫癌等疾病中的重要生物标志物，与疾病预后和治疗效果相关。虽然受体状态目前通过免疫组织化学测定来确定，但非侵入性PR成像剂的开发可以改善分子表征，治疗决策和疾病监测。ProGlo是一种甾酮结合的磁共振成像（MRI）造影剂，在体内进行了评价，以确定其是否靶向表达高PR水平的器官和肿瘤并增强其信号强度。一项组织分布研究表明，ProGlo在富含PR的子宫中蓄积，这一点通过体内成像研究得到证实。这些器官的离体图像显示ProGlo分布在表达高PR水平的亚结构中。在异种移植肿瘤模型中，ProGlo在肿瘤中，特别是在PR（+）肿瘤中比非功能化的Gd-DO 3A更大程度地被摄取。在PR（+）器官和肿瘤中积累和增强信号强度的能力表明，ProGlo可能是PR（+）疾病的有前途的MRI探针。
Progesterone receptor (PR) is a significant biomarker in diseases such as endometriosis and breast, ovarian, and uterine cancers that is associated with disease prognosis and therapeutic efficacy. While receptor status is currently determined by immunohistochemistry assays, the development of noninvasive PR imaging agents could improve molecular characterization, treatment decisions, and disease monitoring. ProGlo, a progesterone-conjugated magnetic resonance imaging (MRI) contrast agent, was evaluated in vivo to determine whether it targets and enhances signal intensity in organs and tumors that express high PR levels. A tissue distribution study indicated that ProGlo accumulates in the PR-rich uterus, which was confirmed by in vivo imaging studies. Ex vivo images of these organs revealed that ProGlo was distributed in the substructures that express high PR levels. In xenograft tumor models, ProGlo was taken up to a greater extent than the non-functionalized Gd-DO3A in tumors, particularly in PR(+) tumors. The ability to accumulate and enhance signal intensity in PR(+) organs and tumors suggest that ProGlo may be a promising MRI probe for PR(+) diseases.
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影响因子：
2.4
作者：
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通讯作者：
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影响因子：
120.1
作者：
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通讯作者：
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DOI：
10.1023/b:jomg.0000010028.48159.84
发表时间：
2003-07-01
影响因子：
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作者：
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通讯作者：
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影响因子：
158.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Uppal, Ritika