Ethanol-induced increase in procainamide acetylation in man.
Ethanol-induced increase in procainamide acetylation in man.
复制标题
乙醇诱导的人体普鲁卡因酰胺乙酰化增加。
DOI：
10.1111/j.1365-2125.1982.tb01357.x
复制
发表时间：
1982
影响因子：
3.4
通讯作者：
J. Mørland
中科院分区：
文献类型：
--
作者：
H. Olsen;J. Mørland
1采用两种不同的实验设计，研究乙醇对普鲁卡因胺人体药代动力学的影响。其中一组在服药后1.5小时给予乙醇，然后每小时饮用一次，而另一组在服药前和服药后2小时分别给予乙醇。2在这两项研究中，乙醇引起t1/2显著降低和普鲁卡因胺的总清除量显著增加，而普鲁卡因胺的表观分布体积以及普鲁卡因胺和N-乙酰普鲁卡因胺的肾脏清除量均不受乙醇处理的影响。3乙醇处理显著增加血和尿中N-乙酰普鲁卡因胺的百分含量和AUCNAPA/AUCPA的比值。4慢速乙酰化器与快速乙酰化器的普鲁卡因胺的T1/2和总清除量有显著差异。
1 The effect of ethanol on procainamide pharmacokinetics was studied in humans by two different experimental designs. In one, ethanol was given 1.5 h after taking the drug followed by hourly drinks, while in the other ethanol was given 2 h before and subsequently after taking the drug. 2 In both studies, ethanol caused a significant reduction of T1/2 and a significant increase in total clearance of procainamide, while the apparent volume of distribution of procainamide, as well as the renal clearance of both procainamide and N-acetylprocainamide were unaffected by ethanol treatment. 3 Ethanol treatment increased the percentage of N-acetylprocainamide measured in blood and urine and the ratio of AUCNAPA/AUCPA significantly. 4 The T1/2 and total clearance of procainamide was significantly different in slow and rapid acetylators.