HLA class I and class II frequencies of a Hong Kong Chinese population based on bone marrow donor registry data
HLA class I and class II frequencies of a Hong Kong Chinese population based on bone marrow donor registry data
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DOI：
10.1016/s0198-8859(97)00108-0
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发表时间：
1997-08-01
期刊：
影响因子：
2.7
通讯作者：
Hawkins, BR
中科院分区：
文献类型：
--
作者：
Chang, YW;Hawkins, BR
HLA-A和-B抗原，基因和单倍型频率已计算从18,774名中国南方的骨髓捐献者在香港的注册。250例供者也用PCR-SSP技术检测了HLA-DRB 1、-DQA 1和-DQB 1等位基因。41个HLA-A，-B组合在理论上可能的单倍型数调整后在0.05水平上显示统计学上显著的正连锁不平衡，43个显示显著的负连锁不平衡。共鉴定出39种不同的DRB 1-DQA 1-DQB 1单倍型，其中20种出现5次或更多次。DRB 1 *0901-DQA 1 *0301-DQB 1 *0303是最常见的单倍型，单倍型频率为0.1620。本文首次报道DQA 1 *0104、DQA 1 *05011和DQA 1 *05012/13等位基因在中国人中的分布。这些数据对于系统发育、比较和法医学研究非常重要，对于估计等待骨髓移植的中国患者获得适当匹配供体的可能性特别有价值。(C)美国组织相容性和免疫遗传学学会，1997年。出版社：Elsevier Science Inc.
HLA-A, and -B antigen, gene and haplotype frequencies have been calculated from 18,774 southern Chinese donors on a Hong Kong-based bone marrow donor registry. Two hundred and fifty donors were also tested for HLA-DRB1, -DQA1, and -DQB1 alleles using the PCR-SSP technique. Forty-one HLA-A, -B combinations showed statistically significant positive linkage disequilibrium at the 0.05 level after adjustment for the number of haplotypes theoretically possible and 43 showed significant negative disequilibrium. Thirty-nine different DRB1-DQA1-DQB1 haplotypes were identified of which 20 occurred 5 or more times. The most prevalent was DRB1*0901-DQA1*0301-DQB1*0303 (haplotype frequency = 0.1620). This is the first paper to report the distribution of DQA1*0104, DQA1*05011 and DQA1*05012/13 alleles in Chinese. These data are important for phylogenetic, comparative and medico-legal studies and are of particular value in estimating the likelihood of obtaining appropriately matched donors for Chinese patients awaiting bone marrow transplantation. (C) American Society for Histocompatibility and Immunogenetics, 1997. Published by Elsevier Science Inc.