Proteases and bacterial virulence: a view from the trenches.
Proteases and bacterial virulence: a view from the trenches.
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发表时间：
1995-03
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通讯作者：
J. Goguen;N. Hoe;Y. Subrahmanyam
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作者：
J. Goguen;N. Hoe;Y. Subrahmanyam
许多种类的病原菌产生细胞表面或分泌的蛋白酶。这些酶具有通过降解关键宿主蛋白和通过模拟控制重要酶原系统的宿主调节蛋白酶的活性来增强细菌致病性的高潜力。尽管许多细菌蛋白酶与毒力有关，但目前还没有一个系统既能严格证明体内毒力增强，又能令人信服地鉴定出重要的底物分子。固有的困难，在解决这些问题进行了讨论，并简要介绍了几个有趣的系统正在积极调查。还考虑了细胞外蛋白酶作为药物开发靶点的潜力。
Many species of pathogenic bacteria produce cell-surface or secreted proteases. These enzymes have high potential to enhance bacterial pathogenesis through degradation of critical host proteins and by mimicking the activity of host regulatory proteases that control important zymogen systems. Although many bacterial proteases have been implicated in virulence, there is currently no system in which both rigorous demonstration of virulence enhancement in vivo and convincing identification of the important substrate molecules has been achieved. The difficulties inherent in addressing these issues is discussed, and several interesting systems under active investigation briefly described. The potential of extracellular protease as targets for drug development is also considered.