SIGNIFICANT REDUCTIONS IN SYNAPSIN BUT NOT SYNAPTOPHYSIN SPECIFIC ACTIVITY IN THE BRAINS OF SOME SCHIZOPHRENICS
SIGNIFICANT REDUCTIONS IN SYNAPSIN BUT NOT SYNAPTOPHYSIN SPECIFIC ACTIVITY IN THE BRAINS OF SOME SCHIZOPHRENICS
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DOI：
10.1016/0006-3223(93)90195-j
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发表时间：
1993-10-15
影响因子：
10.6
通讯作者：
FREEDMAN, R
中科院分区：
文献类型：
--
作者：
BROWNING, MD;DUDEK, EM;FREEDMAN, R
采用定量western blot方法检测了来自精神分裂症患者和年龄匹配对照组的人类死后海马中突触囊泡相关蛋白突触素和突触素的水平。精神分裂症患者的突触素I水平明显低于对照组。在个体数据中，7名精神分裂症患者样本中有1人的突触素水平极低，而2名精神分裂症患者的突触素水平正常。突触素的缺失似乎不是由于某些非特异性神经元的缺失，因为在所有7名精神分裂症患者中，另一种突触囊泡标记物突触素的水平接近正常。考虑到突触素被认为调节神经递质释放，突触素的缺陷可能导致神经元信息处理异常，正如精神分裂症相关的各种感觉处理异常所见。
The levels of the synaptic vesicle-associated proteins, synapsin and synaptophysin, were examined in human postmortem hippocampus from the brains of schizophrenics and age-matched controls using a quantitative western blot analysis. The schizophrenic samples had significantly lower levels of synapsin I than controls. In individual data, Jive of the seven schizophrenic samples had extremely low levels of synapsin, whereas two of the schizophrenic samples had normal levels of synapsin. This deficit in synapsin does nat appear to be due to some non-specific neuronal loss as the levels of the other synaptic vesicle marker, synaptophysin, were near normal in all seven schizophrenics. Given that synapsin is thought to regulate neurotransmitter release, it is possible that this deficit in synapsin could result in abnormal processing of neuronal information as is seen in various sensory processing abnormalities associated with schizophrenia.