Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.
Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.
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Kv3 通道可用性的快速状态相关改变驱动依赖于体细胞阈下去极化的灵活突触信号传导。
DOI：
10.1016/j.celrep.2017.01.068
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发表时间：
2017
期刊：
影响因子：
8.8
通讯作者：
Christie,JasonM
中科院分区：
文献类型：
--
作者：
Rowan,MatthewJM;Christie,JasonM
In many neurons, subthreshold depolarization in the soma can transiently increase action-potential (AP)-evoked neurotransmission via analog-to-digital facilitation. The mechanisms underlying this form of short-term synaptic plasticity are unclear, in part, due to the relative inaccessibility of the axon to direct physiological interrogation. Using voltage imaging and patch-clamp recording from presynaptic boutons of cerebellar stellate interneurons, we observed that depolarizing somatic potentials readily spread into the axon, resulting in AP broadening, increased spike-evoked Ca2+entry, and enhanced neurotransmission strength. Kv3 channels, which drive AP repolarization, rapidly inactivated upon incorporation of Kv3.4 subunits. This leads to fast susceptibility to depolarization-induced spike broadening and analog facilitation independent of Ca2+-dependent protein kinase C signaling. The spread of depolarization into the axon was attenuated by hyperpolarization-activated currents (Ihcurrents) in the maturing cerebellum, precluding analog facilitation. These results suggest that analog-to-digital facilitation is tempered by development or experience in stellate cells.
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桥本氏病（淋巴结肿大）的自身抗体。
影响因子：
168.9
作者：
I. Roitt;D. Doniach;P. Campbell;R. Hudson
通讯作者：
R. Hudson
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DOI：
--
发表时间：
1963
期刊：
The Lancet
影响因子：
--
作者：
R. B. Goudie;H. Mccallum
通讯作者：
H. Mccallum
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影响因子：
15.3
作者：
E. Khoury;G. Bottazzo;I. Roitt
通讯作者：
I. Roitt
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影响因子：
64.8
作者：
M. Shulman;C. Wilde;G. Köhler
通讯作者：
G. Köhler
与多个内分泌器官发生反应的人单克隆自身抗体。
DOI：
10.1056/nejm198307283090405
发表时间：
1983
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Satoh;B. Prabhakar;M. Haspel;F. Ginsberg‐Fellner;A. Notkins
通讯作者：
A. Notkins