A Single Case Observation: Is the Ebola Virus Soluble Glycoprotein an Indicator of Viral Recrudescence?
A Single Case Observation: Is the Ebola Virus Soluble Glycoprotein an Indicator of Viral Recrudescence?
复制标题
个案观察：埃博拉病毒可溶性糖蛋白是病毒复发的指标吗？
DOI：
10.1093/infdis/jiad279
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Marzi,Andrea
中科院分区：
文献类型：
--
作者：
Furuyama,Wakako;Davey,RichardT;Chertow,DanielS;Marzi,Andrea
本病例研究调查了一名患者血清中埃博拉病毒（EBOV）可溶性糖蛋白（sGP）的长期表达动态，该患者在马里兰州贝塞斯达的国立卫生研究院临床中心感染了西非的EBOV，并从急性埃博拉病毒病（EVD）中恢复。在急性EVD期间和疾病发作后第361天的恢复期采集该患者的样本。虽然从急性EVD恢复后，通过逆转录-定量聚合酶链反应检测血液样本为阴性，但我们在患者恢复后很长时间内在血清中检测到少量EBOV sGP，这可能表明病毒复发。由于这仅在单个患者中观察到，因此需要额外的纵向患者样本来证实我们的假设，即EBOV sGP可能是急性EVD恢复后很长时间内病毒复发的指标。
This case study investigated the long-term expression dynamics of Ebola virus (EBOV) soluble glycoprotein (sGP) in the serum of a patient who was infected with EBOV in West Africa and recovered from acute Ebola virus disease (EVD) at the National Institutes of Health Clinical Center in Bethesda, Maryland. Samples from this patient were collected during acute EVD and during convalescence up to day 361 following illness onset. Although blood samples were negative by reverse transcription–quantitative polymerase chain reaction after recovery from acute EVD, we detected small amounts of EBOV sGP in the serum of the patient long after recovery, potentially indicating viral recrudescence. As this was only observed in a single patient, additional longitudinal patient samples are needed to confirm our hypothesis that EBOV sGP may be an indicator of viral recrudescence long after recovery from acute EVD.