Eight unique basal bodies in the multi-flagellated diplomonad Giardia lamblia.
Eight unique basal bodies in the multi-flagellated diplomonad Giardia lamblia.
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DOI：
10.1186/s13630-016-0042-4
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Dawson, Scott C
中科院分区：
文献类型：
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作者：
McInally, Shane G;Dawson, Scott C
蓝氏贾第虫是一种肠道寄生原生生物，在世界范围内引起严重的急性和慢性肠道疾病。贾第鞭毛虫属的原生生物群是掘孔虫超类群中的一个类群。双单胞菌的特点是由八个运动鞭毛组织成四个双边对称对。八个贾第鞭毛虫轴丝中的每一个都有一个长的细胞质区域，该区域在作为膜结合鞭毛离开细胞体之前从位于中心的基体延伸。因此，每个基体在其细胞学位置和与不同细胞骨架特征的关联上是独特的，包括腹盘、轴丝和轴丝外结构。这些独特而复杂的细胞骨架元件的遗传通过基体迁移、复制、成熟以及它们随后在细胞分裂期间与特定纺锤体极的关联来维持。由于特殊的基体及其相关结构的复杂组成和遗传，贾第虫可能需要新的基体相关蛋白。因此，原生生物，如贾第虫可能代表了一个未发现的新的基体相关蛋白质的来源。使贾第虫易于遗传的新工具的开发将使八个基体的组成，结构和功能得到更彻底的探索。
Giardia lamblia is an intestinal parasitic protist that causes significant acute and chronic diarrheal disease worldwide. Giardia belongs to the diplomonads, a group of protists in the supergroup Excavata. Diplomonads are characterized by eight motile flagella organized into four bilaterally symmetric pairs. Each of the eight Giardia axonemes has a long cytoplasmic region that extends from the centrally located basal body before exiting the cell body as a membrane-bound flagellum. Each basal body is thus unique in its cytological position and its association with different cytoskeletal features, including the ventral disc, axonemes, and extra-axonemal structures. Inheritance of these unique and complex cytoskeletal elements is maintained through basal body migration, duplication, maturation, and their subsequent association with specific spindle poles during cell division. Due to the complex composition and inheritance of specific basal bodies and their associated structures, Giardia may require novel basal body-associated proteins. Thus, protists such as Giardia may represent an undiscovered source of novel basal body-associated proteins. The development of new tools that make Giardia genetically tractable will enable the composition, structure, and function of the eight basal bodies to be more thoroughly explored.