Drug abuse as a problem of impaired control: current approaches and findings.
Drug abuse as a problem of impaired control: current approaches and findings.
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DOI：
10.1177/1534582303257007
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发表时间：
2003-09-01
期刊：
影响因子：
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通讯作者：
Fillmore, Mark T
中科院分区：
文献类型：
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作者：
Fillmore, Mark T
作者对当前研究滥用药物对人类行为控制方面的急性影响进行了选择性和综合性的概述。该综述讨论了行为控制的概念，并回顾了将抑制影响作为控制中心机制的研究模型。从当前的神经解剖学、神经药理学和行为学角度回顾了药物引起的抑制机制损伤的证据。描述了基于模型的行为控制实验室评估在行为药理学中的应用，并回顾了酒精和精神兴奋剂对基本抑制机制影响的证据。药物对抑制机制的影响也根据其与高阶认知和行为功能的相关性以及与冲动行为（例如药物滥用）的相关性进行了讨论。该综述最后确定了重要的药物相关现象（例如药物耐受性、线索反应性），这些现象也可能在未来研究的行为控制框架中进行研究。
The author presents a selective and integrative overview of current research examining acute effects of abused drugs on aspects of behavioral control in humans. The review discusses the concept of behavioral control and reviews research models that examine inhibitory influences as a central mechanism of control. Evidence for drug-induced impairment of inhibitory mechanisms is reviewed from current neuroanatomical, neuropharmacological, and behavioral perspectives. Model-based laboratory assessments of behavioral control are described in terms of their application to behavioral pharmacology and evidence for alcohol and psychostimulant effects on basic inhibitory mechanisms is reviewed. Drug effects on inhibitory mechanisms are also discussed in terms of their relevance to higher-order cognitive and behavioral functions, and in relation to impulsive behaviors, such as drug abuse. The review concludes by identifying important drug-related phenomenon (e.g., drug tolerance, cue reactivity) that might also be studied in behavioral control frameworks in future research.