Bioassay of Kinship in Populations of Middle Eastern Origin and Controls [and Comments and Replies]
Bioassay of Kinship in Populations of Middle Eastern Origin and Controls [and Comments and Replies]
复制标题
中东群体亲缘关系生物测定和对照[以及评论和答复]
作者：
N. Morton;Ron S. Kenett;S. Yee;R. Lew;Milton Alter;E. Azevêdo;I. Barrai;L. L. Cavalli;R. Chakraborty;M. Goldstein;P. James;M. Kamali;E. Kobyliansky;S. Micle;K. Weiss
32个群体的基因频率显示3个犹太族和4个非犹太族。从表型频率来看，中东人群的近交F估计值为0.0110，其他人群的近交F估计值为0.0002。与整个物种的分化（F =.146）相比，该地区的种群分化较小（F =.026）。族群之间的亲缘关系在族群内是可观的，但在整个犹太人和非犹太人群体中则要少得多（分别为0.004和0.001）。群体内部和群体之间因距离而产生的隔离是相似的。从现有的数据来看，主要的犹太人口似乎以每一代约1%的速度与非犹太人混合，导致总混合率约为50%。从这些数据的进化规模估计表明大量的创始人效应。这些结果与Cavalli-Sforza和Carmeli的推论以及Karlin等人的非参数分析定性一致，但不是对后者的某些解释。
Gene frequencies for 32 populations show 3 Jewish and 4 gentile clusters. From phenotype frequencies the estimate of inbreeding F is .0110 for populations in the Middle East and .0002 for other populations. Differentiation of populations in the region is small (F =.026) compared with that of the species as a whole (F =.146). Kinship between populations is appreciable within clusters but much less within the total Jewish and gentile groups (.004 and .001, respectively). Isolation by distance is similar within and between groups. From the available data the major Jewish populations appear to have undergone admixture with gentiles at a rate of about 1% per generation, leading to total admixture rates of about 50%. Estimates of evolutionary size from these data suggest substantial founder effects. These results are qualitatively consistent with inferences of Cavalli-Sforza and Carmelli and with the nonparametric analysis of Karlin et al., but not with some interpretations of the latter.