Association between brain-derived neurotrophic factor val66met gene polymorphism and progressive brain volume changes in schizophrenia
Association between brain-derived neurotrophic factor val66met gene polymorphism and progressive brain volume changes in schizophrenia
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DOI：
10.1176/appi.ajp.2007.05111903
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发表时间：
2007-12-01
影响因子：
17.7
通讯作者：
Wassink, Thomas H.
中科院分区：
文献类型：
--
作者：
Ho, Beng-Choon;Andreasen, Nancy C.;Wassink, Thomas H.
目的：精神分裂症进行性脑体积变化的潜在因素仍然知之甚少。作者调查是否影响神经可塑性的基因多态性可能有助于纵向brain volume alterations.Method：高分辨率磁共振（MR）图像的全脑获得了119例新发精神分裂症谱系障碍。比较了脑源性神经营养因子（BDNF）va166met基因型组之间平均3年的脑体积变化。进行了探索性分析，以探讨抗精神病药物治疗和脑容量的变化之间的关系，以及BDNF基因型对认知和症状的变化的影响：观察到显着的基因型效应的额叶灰质，侧脑室，脑沟CSF的体积内的主题变化。与瓦尔纯合子患者相比，Met等位基因携带者的额叶灰质体积显著减少，侧脑室和脑沟（特别是额叶和颞叶）CSF的体积相应增加。与BDNF基因型无关，MRI扫描之间更多的抗精神病药物暴露与额叶灰质体积减少相关，特别是在最初未经治疗的患者中。有没有统计学显着的基因型效应内的主题变化认知或symptoms.Conclusions：BDNF Met变异可能是影响进行性脑容量变化的精神分裂症的几个因素之一。
Objective: Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations.Method: High-resolution magnetic resonance (MR) images of the whole brain were obtained for 119 patients with recent-onset schizophrenia spectrum disorders. Changes in brain volumes over an average of 3 years were compared between brain-derived neurotrophic factor (BDNF) va166met genotype groupings. Exploratory analyses were conducted to examine relationships between antipsychotic treatment and brain volume changes as well as the effects of BDNF genotype on changes in cognition and symptoms.Results: Significant genotype effects were observed on within-subject changes in volumes of frontal lobe gray matter, lateral ventricles, and sulcal CSF. Met allele carriers had significantly greater reductions in frontal gray matter volume, with reciprocal volume increases in the lateral ventricles and sulcal (especially frontal and temporal) CSF than Val homozygous patients. Independent of BDNF genotype, more antipsychotic exposure between MRI scans correlated with greater volume reductions in frontal gray matter, particularly among patients who were initially treatment naive. There were no statistically significant genotype effects on within-subject changes in cognition or symptoms.Conclusions: BDNFMet variant may be one of several factors affecting progressive brain volume changes in schizophrenia.