Oscillatory responses to reward processing in borderline personality disorder
Oscillatory responses to reward processing in borderline personality disorder
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边缘型人格障碍患者对奖赏处理的振荡反应
DOI：
10.3109/15622975.2015.1054880
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发表时间：
2015-11-17
影响因子：
3.1
通讯作者：
Mulert, Christoph
中科院分区：
文献类型：
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作者：
Andreou, Christina;Kleinert, Julia;Mulert, Christoph
目标。先前的电生理学研究证实了BPD患者的奖励处理受损。然而，目前尚不清楚奖励处理的哪些方面受到影响，以及哪些大脑区域参与其中。本研究调查了反馈事件的诱发和诱导事件相关振荡（EROs）（被认为代表了反馈处理的不同方面），并使用源定位（sLORETA）来评估两个已知有助于奖励处理的区域的活动，即背内侧前额叶/前扣带皮层（dmPFC/ACC）和眶额皮质（OFC）。方法。18名BPD患者和22名健康对照者进行赌博任务，同时记录64通道脑电图活动。根据反馈事件的效价和大小，研究了诱发和诱导的θ和高β波段EROs以及两个感兴趣区域的活动。结果。BPD患者对负反馈的theta波段反应减少，这一效应仅涉及诱发反应和dmPFC/ ACC区域，并且与患者的特质冲动有关。sLORETA分析显示，受干扰的诱发反应取决于θ (OFC)和高β （dmPFC/ACC和OFC）频率范围内的反馈幅度。结论。结果表明BPD患者存在多重反馈加工功能障碍，暗示了几种不同的奖励加工机制子集。
Objectives. Previous electrophysiological studies have confirmed impaired reward processing in patients with BPD. However, it is not clear which aspects of reward processing are affected and which brain regions are involved. The present study investigated both evoked and induced event-related oscillations (EROs) to feedback events (thought to represent different aspects of feedback processing), and used source localization (sLORETA) to assess activity in two areas known to contribute to reward processing, the dorsomedial prefrontal/anterior cingulate cortex (dmPFC/ACC) and the orbitofrontal cortex (OFC). Methods. Eighteen patients with BPD and 22 healthy controls performed a gambling task, while 64-channel electroencephalographic activity was recorded. Evoked and induced theta and high-beta band EROs as well as activity in the two regions of interest were investigated depending on the valence and magnitude of feedback events. Results. Theta-band responses to negative feedback were reduced in BPD, an effect that involved only evoked responses and the dmPFC/ ACC region, and was associated with trait impulsivity in patients. sLORETA analyses revealed disturbed evoked responses depending on feedback magnitude in the theta (OFC) and high-beta (dmPFC/ACC and OFC) frequency range. Conclusions. The results indicate multiple dysfunctions of feedback processing in patients with BPD, implicating several distinct subsets of reward-processing mechanisms.