Control of Epstein-Barr Virus (EBV) in the Oral Cavity Is Associated With Persistence of Oral Human Papillomavirus (HPV)16/18 Among Men From the HPV Infection in Men Study.
Control of Epstein-Barr Virus (EBV) in the Oral Cavity Is Associated With Persistence of Oral Human Papillomavirus (HPV)16/18 Among Men From the HPV Infection in Men Study.
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根据男性 HPV 感染研究，口腔中 Epstein-Barr 病毒 (EBV) 的控制与男性口腔人乳头瘤病毒 (HPV)16/18 的持续存在相关。
DOI：
10.1093/infdis/jiac223
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Coghill,AnnaE
中科院分区：
文献类型：
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作者：
Dickey,BrittneyL;Giuliano,AnnaR;Sirak,Bradley;Abrahamsen,Martha;Lazcano-Ponce,Eduardo;Villa,LuisaL;Coghill,AnnaE
背景：人乳头瘤病毒（HPV）相关口咽癌（OPC）的发病率在男性中呈上升趋势。需要能够识别可能持续存在的口服HPV16/18感染的生物标志物，这是HPV-OPC的专性前体。方法对63名男性HPV感染研究中HPV16/18检测呈阳性的男性进行口腔EBV （Epstein-Barr virus， EBV）与口腔HPV16/18持续性的关系进行评估。控制口腔合并感染，包括EBV，可以作为免疫能力和控制口腔HPV能力的生物标志物。结果口腔EBV检测与HPV16/18≥12个月持续时间显著相关。结论口腔EBV检测作为口腔HPV持续性和HPV相关OPC的生物标志物值得评价。
BackgroundHuman papillomavirus (HPV)-related oropharyngeal cancer (OPC) incidence is increasing among men. Biomarkers that can identify oral HPV16/18 infections likely to persist, the obligate precursor for HPV-OPC, are needed.MethodsWe assessed the association between oral Epstein-Barr virus (EBV) and oral HPV16/18 persistence among 63 men in the HPV Infection in Men Study who tested positive for HPV16/18 at the baseline visit. Control of oral coinfections, including EBV, could serve as a biomarker of immune competence and the ability to control oral HPV.ResultsDetection of oral EBV was significantly associated with oral HPV16/18 ≥12-month persistence.ConclusionsDetection of oral EBV deserves evaluation as a biomarker for oral HPV persistence and HPV-related OPC.