Influence of culturing on the functioning of major-histocompatibility-complex-compatible and incompatible islet grafts in diabetic mice.
Influence of culturing on the functioning of major-histocompatibility-complex-compatible and incompatible islet grafts in diabetic mice.
复制标题
培养对糖尿病小鼠主要组织相容性复合物相容性和不相容性胰岛移植物功能的影响。
DOI：
10.1097/00007890-198336060-00020
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发表时间：
1983
期刊：
影响因子：
6.2
通讯作者：
Barker,CF
中科院分区：
文献类型：
--
作者：
Bartlett,ST;Naji,A;Silvers,WK;Barker,CF
培养 B10。 BR (H-2 k) 胰岛在主要组织相容性复合体 (MHC) 不相容的 BALB/c (H-2 d) 小鼠中促进其存活，但在 MHC 相容性 CBA (H-2 k) 动物中则不然。这些结果提供了进一步的证据，表明MHC限制涉及移植免疫，即同种异体移植物只有在拥有供体巨噬细胞（或该家族的细胞）时才被识别为外来物，或者如果宿主可以提供与移植物MHC相容的抗原呈递细胞。
Culturing B10. BR (H-2 k) islets promotes their survival in major histocompatibility complex (MHC)-incompatible BALB/c (H-2 d) mice, but not in MHC-compatible CBA (H-2 k) animals. These results provide further evidence that MHC restriction is involved in transplantation immunity—ie, that allografts are only recognized as foreign if they possess donor macrophages (or cells of this family), or if antigen-presenting cells MHC-compatible with the graft can be provided by the host.