Serum Hemagglutination Inhibition Activity Correlates with Protection from Gastroenteritis in Persons Infected with Norwalk Virus
Serum Hemagglutination Inhibition Activity Correlates with Protection from Gastroenteritis in Persons Infected with Norwalk Virus
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DOI：
10.1128/cvi.05592-11
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发表时间：
2012-02-01
影响因子：
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通讯作者：
Estes, Mary K.
中科院分区：
文献类型：
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作者：
Czako, Rita;Atmar, Robert L.;Estes, Mary K.
建立了诺瓦克病毒感染后血凝抑制（HAI）测定血清抗体反应的方法。在实验感染NV的个体（n = 18）中，HAI活性显著增加，并与组织血型抗原（HBGA）阻断试验中测量的抗体水平相关。攻毒前HAI抗体水平也与预防胃肠炎的发生相关（Mann-Whitney检验，P = 0.02）。HAI试验是另一种适用于检测与诺瓦克病毒相关疾病保护相关的抗体的试验。
A hemagglutination inhibition (HAI) assay to assess serum antibody responses following Norwalk virus (NV) infection was developed. HAI activity increased significantly in individuals experimentally infected with NV (n = 18) and correlated with antibody levels measured in a histo-blood group antigen (HBGA) blocking assay. Prechallenge HAI antibody levels also correlated with protection from the development of gastroenteritis (Mann-Whitney test, P = 0.02). The HAI assay is another assay suitable for the detection of antibody that correlates with protection from Norwalk virus-associated disease.