18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases
18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases
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DOI：
10.1007/s00259-020-04734-w
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发表时间：
2020-02-22
影响因子：
9.1
通讯作者：
Lan, Xiaoli
中科院分区：
文献类型：
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作者：
Qin, Chunxia;Liu, Fang;Lan, Xiaoli
目的本病例系列旨在说明中国湖北省武汉市COVID-19引起的急性呼吸道疾病患者的F-18-FDG PET/CT表现。方法我们描述了2020年1月13日至1月20日期间因呼吸道症状和发热入院的4名患者的F-18-FDG PET/CT结果，当时COVID-19疫情尚未被识别，病毒传染性未知。对患者病史、临床和实验室数据以及影像学检查结果的回顾性审查强烈建议诊断为COVID-19。结果所有患者均有两个以上肺叶周围磨玻璃样影和/或肺实变。肺部病变的特点是高F-18-FDG摄取，并有淋巴结受累的证据。相反，不存在播散性疾病，这一发现表明COVID-19具有肺嗜性。结论虽然F-18-FDG PET/CT不能常规用于急诊，通常不推荐用于感染性疾病，但我们的试点数据揭示了这种成像技术在复杂病例鉴别诊断中的潜在临床应用。
Purpose The aim of this case series is to illustrate the F-18-FDG PET/CT findings of patients with acute respiratory disease caused by COVID-19 in Wuhan, Hubei province of China. Methods We describe the F-18-FDG PET/CT results from four patients who were admitted to the hospital with respiratory symptoms and fever between January 13 and January 20, 2020, when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. A retrospective review of the patients' medical history, clinical and laboratory data, as well as imaging findings strongly suggested a diagnosis of COVID-19. Results All patients had peripheral ground-glass opacities and/or lung consolidations in more than two pulmonary lobes. Lung lesions were characterized by a high F-18-FDG uptake and there was evidence of lymph node involvement. Conversely, disseminated disease was absent, a finding suggesting that COVID-19 has pulmonary tropism. Conclusions Although F-18-FDG PET/CT cannot be routinely used in an emergency setting and is generally not recommended for infectious diseases, our pilot data shed light on the potential clinical utility of this imaging technique in the differential diagnosis of complex cases.