Development and tissue origins of the mammalian cranial base
Development and tissue origins of the mammalian cranial base
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DOI：
10.1016/j.ydbio.2008.07.016
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发表时间：
2008-10-01
影响因子：
2.7
通讯作者：
Morriss-Kay, G. M.
中科院分区：
文献类型：
--
作者：
McBratney-Owen, B.;Iseki, S.;Morriss-Kay, G. M.
脊椎动物的颅底是一个复杂的结构，由骨，软骨和其他结缔组织组成的大脑下面;它与面部和颅穹窿的发育密切相关。尽管其在颅面发育中的中心重要性，但颅底的形态发生和组织起源尚未在小鼠（一种重要的模式生物）中详细研究。我们在这里描述的位置和时间出现的软骨颅。我们还研究了使用神经嵴细胞谱系细胞标记物Wnt 1-Cre/R26 R和中胚层谱系细胞标记物Mesp 1-Cre/R26 R的小鼠颅底的组织起源。软骨颅在小鼠的E11和E16之间发育，开始于尾部（枕骨）软骨颅的发育，随后是喙部软骨形成以形成鼻囊，最后这两个部分通过中线中央茎和穹窿软骨的侧向支柱融合。从出生后E8.0至10天的转基因小鼠的X-Gal染色显示，神经嵴细胞有助于形成筛骨、蝶骨前骨和蝶骨基的所有软骨，但下交叉软骨除外。基枕骨和颞骨的非鳞状部分来自中胚层。因此，索前头部主要由神经嵴衍生的组织组成，正如新头部假说所预测的那样。然而，与眼外肌紧密相连的中胚层来源的下视交叉软骨的前部位置表明，与视觉器官相关的一些组织可能独立于“新头部”的其余部分进化。(c)2008年爱思唯尔公司All rights reserved.
The vertebrate cranial base is a complex Structure composed of bone, cartilage and other connective tissues underlying the brain; it is intimately connected with development of the face and cranial vault. Despite its central importance in craniofacial development, morphogenesis and tissue origins of the cranial base have not been studied in detail in the mouse, an important model organism. We describe here the location and time of appearance of the cartilages of the chondrocranium. We also examine the tissue origins of the mouse Cranial base using a neural crest cell lineage cell marker, Wnt1-Cre/R26R, and a mesoderm lineage cell marker, Mesp1-Cre/R26R. The chondrocranium develops between Ell and E16 in the mouse, beginning with development of the caudal (occipital) chondrocranium, followed by chondrogenesis rostrally to form the nasal capsule, and finally fusion of these two parts via the midline central stem and the lateral struts of the Vault cartilages. X-Gal staining of transgenic mice from E8.0 to 10 days post-natal showed that neural crest cells contribute to all of the cartilages that form the ethmoid, presphenoid, and basisphenoid bones with the exception of the hypochiasmatic cartilages. The basioccipital bone and non-squamous parts of the temporal bones are mesoderm derived. Therefore the prechordal head is mostly composed of neural crest-derived tissues, as predicted by the New Head Hypothesis. However, the anterior location of the mesoderm-derived hypochiasmatic cartilages, which are closely linked with the extra-ocular muscles, suggests that some tissues associated with the Visual apparatus may have evolved independently of the rest of the "New Head". (c) 2008 Elsevier Inc. All rights reserved.