A cluster randomized controlled trial evaluating the efficacy of peer mentors to support South African women living with HIV and their infants.
A cluster randomized controlled trial evaluating the efficacy of peer mentors to support South African women living with HIV and their infants.
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DOI：
10.1371/journal.pone.0084867
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Stein A
中科院分区：
文献类型：
--
作者：
Rotheram-Borus MJ;Richter LM;van Heerden A;van Rooyen H;Tomlinson M;Harwood JM;Comulada WS;Stein A
我们评估了艾滋病毒阳性的同伴导师，除了标准的诊所护理，对孕产妇和婴儿的福祉之间的妇女艾滋病毒感染者（WLH）从怀孕到婴儿的第一年的生活，以诊所为基础的支持的效果。在南非夸祖鲁-纳塔尔的一项随机分组对照试验中，8家诊所的妊娠WLH患者随机接受标准治疗（SC; 4家诊所; n = 656 WLH）或强化干预（EI; 4家诊所; n = 544 WLH）。 在EI的WLH被邀请参加四个产前和四个产后会议，由艾滋病毒阳性的同伴导师，除了SC。WLH在怀孕期间招募，并至少有两个出生后的评估面试完成了57%的WLH在1.5，6或12个月。EI的效果，确定了19项措施的孕产妇和婴儿的福祉，使用随机效应回归控制临床集群。相关结果的二项检验评估了EI的总体疗效。WLH平均参加了4.1次会议（SD = 2.0）; 13%没有参加任何会议。 使用二项式检验发现，与SC相比，EI具有显著的总体获益。其次，随着时间的推移，在EI中的WLH报告的抑郁症状和体重不足的婴儿比在SC条件下的WLH显着减少。EI WLH明显更有可能使用一种喂养方法6个月，并完全母乳喂养婴儿至少6个月。WLH受益于艾滋病毒阳性同伴导师的支持，即使EI参与是部分的，6-12个月的随访率不完整。ClinicalTrials.gov NCT00972699
We evaluate the effect of clinic-based support by HIV-positive Peer Mentors, in addition to standard clinic care, on maternal and infant well-being among Women Living with HIV (WLH) from pregnancy through the infant's first year of life. In a cluster randomized controlled trial in KwaZulu-Natal, South Africa, eight clinics were randomized for pregnant WLH to receive either: a Standard Care condition (SC; 4 clinics; n = 656 WLH); or an Enhanced Intervention (EI; 4 clinics; n = 544 WLH). WLH in the EI were invited to attend four antenatal and four postnatal meetings led by HIV-positive Peer Mentors, in addition to SC. WLH were recruited during pregnancy, and at least two post-birth assessment interviews were completed by 57% of WLH at 1.5, 6 or 12 months. EI's effect was ascertained on 19 measures of maternal and infant well-being using random effects regressions to control for clinic clustering. A binomial test for correlated outcomes evaluated EI's overall efficacy. WLH attended an average of 4.1 sessions (SD = 2.0); 13% did not attend any sessions. Significant overall benefits were found in EI compared to SC using the binomial test. Secondarily, over time, WLH in the EI reported significantly fewer depressive symptoms and fewer underweight infants than WLH in the SC condition. EI WLH were significantly more likely to use one feeding method for six months and exclusively breastfeed their infants for at least 6 months. WLH benefit by support from HIV-positive Peer Mentors, even though EI participation was partial, with incomplete follow-up rates from 6–12 months. ClinicalTrials.gov NCT00972699
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DOI：
10.1186/1748-5908-1-22
发表时间：
2006-10-03
期刊：
Implementation science : IS
影响因子：
--
作者：
Leshabari SC;Koniz-Booher P;Astrøm AN;de Paoli MM;Moland KM
通讯作者：
Moland KM
DOI：
10.1097/qad.0b013e3283601b53
发表时间：
2013-06-01
期刊：
AIDS (London, England)
影响因子：
--
作者：
le Roux IM;Tomlinson M;Harwood JM;O'Connor MJ;Worthman CM;Mbewu N;Stewart J;Hartley M;Swendeman D;Comulada WS;Weiss RE;Rotheram-Borus MJ
通讯作者：
Rotheram-Borus MJ
影响因子：
2.5
作者：
Rotheram-Borus MJ;Richter L;Van Rooyen H;van Heerden A;Tomlinson M;Stein A;Rochat T;de Kadt J;Mtungwa N;Mkhize L;Ndlovu L;Ntombela L;Comulada WS;Desmond KA;Greco E
通讯作者：
Greco E
DOI：
10.1377/hlthaff.2011.0914
发表时间：
2012-01
期刊：
Health affairs (Project Hope)
影响因子：
--
作者：
Fisher EB;Boothroyd RI;Coufal MM;Baumann LC;Mbanya JC;Rotheram-Borus MJ;Sanguanprasit B;Tanasugarn C
通讯作者：
Tanasugarn C
影响因子：
6.9
作者：
GOLDBERG, DP;HILLIER, VF
通讯作者：
HILLIER, VF