Gene gain and gene loss in Streptococcus:: Is it driven by habitat?
Gene gain and gene loss in Streptococcus:: Is it driven by habitat?
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DOI：
10.1093/molbev/msl115
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发表时间：
2006-12-01
影响因子：
10.7
通讯作者：
Golding, G. Brian
中科院分区：
文献类型：
--
作者：
Marri, Pradeep Reddy;Hao, Weilong;Golding, G. Brian
细菌基因组可以通过基因获得、基因丢失、突变现有基因和/或通过复制现有基因来进化。最近的研究清楚地表明，通过横向基因转移（LGT）获得新基因是细菌进化的主导力量。为了更好地理解LGT的意义，我们采用了比较基因组学方法，使用最大似然法在12个测序的链球菌基因组中模拟种特异性和种内基因插入/缺失（插入/缺失）。本研究表明，基因插入/缺失率是较高的外部分支，并显着不同的物种。我们在这里分析了一些实验特征的物种特异性基因，已获得的LGT，并得出结论，这些基因中至少有一部分在适应中发挥作用。
Bacterial genomes can evolve either by gene gain, gene loss, mutating existing genes, and/or by duplication of existing genes. Recent studies have clearly demonstrated that the acquisition of new genes by lateral gene transfer (LGT) is a predominant force in bacterial evolution. To better understand the significance of LGT, we employed a comparative genomics approach to model species-specific and intraspecies gene insertions/deletions (ins/del among 12 sequenced streptococcal genomes using a maximum likelihood method. This study indicates that the rate of gene ins/del is higher on the external branches and varies dramatically for each species. We have analyzed here some of the experimentally characterized species-specific genes that have been acquired by LGT and conclude that at least a portion of these genes have a role in adaptation.