Molecular Iodine-Mediated Chemoselective Synthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behavior of Natural Amino Acids.
Molecular Iodine-Mediated Chemoselective Synthesis of Multisubstituted Pyridines through Catabolism and Reconstruction Behavior of Natural Amino Acids.
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DOI：
10.1021/acs.orglett.5b03037
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发表时间：
2016-01
期刊：
影响因子：
5.2
通讯作者：
Jia-Chen Xiang;Miao Wang;Yan Cheng;A. Wu
中科院分区：
文献类型：
--
作者：
Jia-Chen Xiang;Miao Wang;Yan Cheng;A. Wu
基于氨基酸的分解代谢和重构行为，开发了一种新的2,6-二取代、2,4,6-三取代和3,5-二取代吡啶的选择性构建方法。用分子碘作为串联催化剂，触发氨基酸的脱羧-脱胺反应，促进随后的吡啶产物的生成。
A new process has been developed for the selective construction of 2,6-disubstituted, 2,4,6-trisubstituted, and 3,5-disubstituted pyridines based on the catabolism and reconstruction behaviors of amino acids. Molecular iodine was used as a tandem catalyst to trigger the decarboxylation-deamination of amino acids and to promote the subsequent formation of the pyridine products.