Neurotoxic effects of cadmium in young rats.
Neurotoxic effects of cadmium in young rats.
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镉对幼年大鼠的神经毒性作用。
DOI：
10.1016/0041-008x(82)90261-7
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发表时间：
1982
影响因子：
3.8
通讯作者：
Klaassen,CD
中科院分区：
文献类型：
--
作者：
Wong,KL;Klaassen,CD
本研究探讨了镉对不同年龄雄性SD大鼠大脑的影响。4日龄大鼠比成年大鼠毒性更大，幼龄大鼠皮下注射镉2和4 mg/kg，老年大鼠皮下注射4 mg/kg和6 mg/kg。低剂量组和高剂量组均无死亡，高剂量组死亡率约10%。4日龄大鼠皮下注射氯化镉(4 mg Cd/kg)后4天，可见穹隆、尾壳核和小脑明显损伤，而2 mg/kg镉仅对小脑造成轻微损伤。4日龄大鼠注射4 mg/kg Cd后19天，可见正常部位可见较大的囊腔。相比之下，镉在注射后4天或19天，在4或6毫克/公斤的剂量下，对成年大鼠没有任何明显的脑损伤。治疗18天后，染镉4 mg/kg的新生大鼠有明显的活动亢进，而染镉2 mg/kg的新生大鼠或染镉4 mg/kg或6 mg/kg的成年大鼠则无明显的过度活动。因此，镉的剂量只会导致几个人死亡，但对新生大鼠的大脑是有毒的，这从多动和损伤中可见一斑。
This study examined the effects of cadmium on the brain of male, Sprague-Dawley rats of different ages. Cadmium was more toxic in 4-day-old than in adult rats, thus 2 and 4 mg/kg were given sc to the younger rats and 4 and 6 mg/kg to the older rats. The lower doses resulted in no mortality and the higher dose about 10% mortality in both groups. Four days after a sc injection of cadmium chloride (4 mg Cd/kg) to 4-day-old rats, lesions were evident in the corpus callosum, caudate-putamen, and cerebellum, while 2 mg/kg of cadmium produced only slight cerebellar damage. Nineteen days after injection of 4 mg Cd/kg to 4-day-old rats, a large cystic cavity was evident where the corpus callosum is normally located. In contrast, cadmium did not produce any observable brain damage in adult rats at 4 or 6 mg/kg, either 4 or 19 days after injection. Eighteen days after treatment, hyperactivity was evident in newborn rats exposed to 4 mg/kg of cadmium, but not in newborn rats exposed to 2 mg/kg of cadmium or in adult rats treated with 4 or 6 mg/kg of cadmium. Thus, cadmium at a dose that produces only a few deaths is toxic to the brain of newborn rats, as evident by hyperactivity and lesions.