Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy
Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy
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光疗促进肿瘤招募和激活自然杀伤 T 细胞，实现有效的癌症免疫治疗
DOI：
10.1021/acs.nanolett.1c02238
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发表时间：
2021-07-15
期刊：
影响因子：
10.8
通讯作者：
Wang, Yucai
中科院分区：
文献类型：
--
作者：
Li, Min;Xie, Di;Wang, Yucai
连续转移的自然杀伤T（NKT）细胞赋予了独特的癌症监测功能，而不会引起明显的副作用，使其成为癌症免疫治疗的有希望的候选者。然而，它们的治疗功效受限于低效的肿瘤浸润和免疫抑制肿瘤微环境中的不充分活化。为了克服这些障碍，我们开发了一种使用光热疗法（PTT）来促进过继转移的NKT细胞的抗肿瘤能力的策略。转移的NKT细胞有效地募集到PTT治疗的肿瘤中，以响应PTT产生的炎症。此外，PTT治疗促进NKT细胞的活化并增强NKT细胞启动的免疫级联反应。因此，PTT加NKT细胞转移的组合疗法表现出对局部肿瘤的优异生长抑制。此外，它有效地排斥远处肿瘤，并增强长期免疫记忆，以防止肿瘤复发。总的来说，目前的研究为NKT细胞用于癌症免疫治疗的临床转化开辟了新的途径。
Adoptively transferred natural killer T (NKT) cells confer distinct cancer surveillance without causing obvious side effects, making them a promising candidate for cancer immunotherapy. However, their therapeutic efficacy is limited by inefficient tumor infiltration and inadequate activation in an immunosuppressive tumor microenvironment. To overcome these obstacles, we develop a strategy of using photothermal therapy (PTT) to promote the antitumor ability of adoptively transferred NKT cells. The transferred NKT cells are efficiently recruited to PTT-treated tumors in response to PTT-created inflammation. Moreover, PTT treatment promotes the activation of NKT cells and enhances the NKT cell-initiated immune cascade. As a consequence, the combined therapy of PTT plus NKT cell transfer exhibits excellent growth inhibition of local tumors. Moreover, it efficiently rejects distant tumors and elicits long-term immunological memory to prevent tumor recurrence. Overall, the current study opens new paths to the clinical translation of NKT cells for cancer immunotherapy.