Associations of Dietary Long-Chain n-3 Polyunsaturated Fatty Acids and Fish With Biomarkers of Inflammation and Endothelial Activation (from the Multi-Ethnic Study of Atherosclerosis [MESA])
Associations of Dietary Long-Chain n-3 Polyunsaturated Fatty Acids and Fish With Biomarkers of Inflammation and Endothelial Activation (from the Multi-Ethnic Study of Atherosclerosis [MESA])
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DOI：
10.1016/j.amjcard.2009.01.016
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发表时间：
2009-05-01
影响因子：
2.8
通讯作者：
Herrington, David
中科院分区：
文献类型：
--
作者：
He, Ka;Liu, Kiang;Herrington, David
已经观察到长链n-3多不饱和脂肪酸（PUFAs）和鱼类消费的心脏保护作用。然而，关于这些饮食因素与炎症和内皮细胞活化的具体关联的数据很少。一项横断面研究对来自多种族动脉粥样硬化研究（MESA）队列的5677名男性和女性进行了研究，包括45至84岁的非裔美国人、高加索人、中国人和西班牙人，且无临床心血管疾病。饮食信息是通过自我管理的食物频率问卷收集的。采用多元线性回归分析来检验长链n-3 PUFAs、非油炸鱼和油炸鱼的摄入量与炎症和内皮细胞激活的生物标志物之间的关系。长链n-3 PUFA摄入量与血浆白细胞介素-6 （p = 0.01）和基质金属蛋白酶-3 （p = 0.03）浓度呈负相关，与年龄、体重指数、体力活动、吸烟、饮酒和饮食变量无关。食用非炸鱼与c反应蛋白（p = 0.045）和白细胞介素-6 （p = 0.045）呈负相关
The cardioprotective effects of long-chain n-3 polyunsaturated fatty acids (PUFAs) and fish consumption have been observed. However, data on the specific associations of these dietary factors with inflammation and endothelial activation are sparse. A cross-sectional study was conducted of 5,677 men and women from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, including African Americans, Caucasians, Chinese, and Hispanics aged 45 to 84 years and free of clinical cardiovascular disease. Dietary information was collected using a self-administered food frequency questionnaire. Multivariate linear regression analyses were used to examine relations between the intake of long-chain n-3 PUFAs, nonfried fish, and fried fish and biomarkers of inflammation and endothelial activation. Long-chain n-3 PUFA intake was inversely associated with plasma concentrations of interleukin-6 (p = 0.01) and matrix metalloproteinase-3 (p = 0.03) independent of age, body mass index, physical activity, smoking, alcohol consumption, and dietary variables. Nonfried fish consumption was inversely related to C-reactive protein (p = 0.045) and interieukin-6 (p