Biological sex impacts COVID-19 outcomes
Biological sex impacts COVID-19 outcomes
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DOI：
10.1371/journal.ppat.1008570
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发表时间：
2020-06-01
期刊：
影响因子：
6.7
通讯作者：
Mauvais-Jarvis, Franck
中科院分区：
文献类型：
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作者：
Klein, Sabra L.;Dhakal, Santosh;Mauvais-Jarvis, Franck
当前的 2019 年新型冠状病毒病 (COVID-19) 大流行揭示了全球男性和女性在疾病结果方面的巨大差异。在美国，对 COVID-19 病例、住院和死亡的男女差异的报告和分析不一致。我们力求提高人们对 COVID-19 导致的男性严重后果的认识，强调机制差异，包括血管紧张素转换酶 2 (ACE2) 的表达和活性以及抗病毒免疫方面的差异。我们还强调了合并症中的性别差异（可能与年龄和种族相关）如何影响 COVID-19 的男性偏向结果。
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.