Multivariate assessment of the central-cardiorespiratory network structure in neuropathological disease
Multivariate assessment of the central-cardiorespiratory network structure in neuropathological disease
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DOI：
10.1088/1361-6579/aace9b
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发表时间：
2018-07
影响因子：
3.2
通讯作者：
S. Schulz;J. Haueisen;K. Bär;A. Voss
中科院分区：
文献类型：
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作者：
S. Schulz;J. Haueisen;K. Bär;A. Voss
目的：网络生理学这一新兴的交叉学科正日益成为医学界关注的焦点。自主神经系统（ANS）功能障碍在精神分裂症（SZO）中有很好的描述。然而，到目前为止，ANS和中枢神经系统（CNS）之间的线性和非线性耦合仅得到部分解决。这种耦合可以被假设为反馈-前馈网络，对内部和外部因素做出灵活和自适应的反应。方法：首次，在这项研究中，我们调查了线性和非线性的短期中枢心肺耦合的17例偏执型SZO患者相比，17名年龄性别匹配的健康受试者分析心率（HR），呼吸（RESP），和功率额脑电图（EEG）活动（PEEG）。目的是确定CNS-ANS的不同监管方面如何影响中枢心肺网络（CCRN）。为了量化CCRN内的这些耦合，应用了归一化的短时部分定向相干和新的多元高分辨率联合符号动力学。主要结果：我们发现，SZO的CCRN可以被描述为双向的，具有更强的中枢驱动机制（PEEG → HR）对HR的调节，而不是相反，呼吸对中枢活动的影响（RESP → PEEG），而不是相反。这表明中枢心肺过程（闭环）主要集中在通过窦房结调整HR，而不是集中在呼吸调节上。另一方面，从ANS到CNS的反馈回路通过呼吸活动强烈地占主导地位。重要性：我们证明了一个相当显着不同的CCRN结构在SZO与强大的中央对心脏系统的影响和强大的呼吸系统的影响。此外，这项研究提供了一个更深入的了解在健康受试者和SZO患者的中央和自主调节网络的相互作用。
Objective: The new interdisciplinary field of network physiology is increasingly becoming a focus of interest in medicine. Autonomic nervous system (ANS) dysfunction is well described in schizophrenia (SZO). However, the linear and nonlinear coupling between the ANS and central nervous system (CNS) has only been partly addressed until now. This coupling can be assumed to be a feedback-feedforward network, reacting with flexible and adaptive responses to internal and external factors. Approach: For the first time, in this study we investigated linear and nonlinear short-term central–cardiorespiratory coupling of 17 patients suffering from paranoid SZO in comparison to 17 age-gender matched healthy subjects analyzing heart rate (HR), respiration (RESP), and the power of frontal electroencephalogram (EEG) activity (PEEG). The objective is to determine how the different regulatory aspects of the CNS-ANS affect the central-cardiorespiratory network (CCRN). To quantify these couplings within the CCRN normalized short time partial directed coherence and the new multivariate high-resolution joint symbolic dynamics were applied. Main results: We found that the CCRN in SZO can be characterized as a bidirectional one, with stronger central driving mechanisms (PEEG → HR) towards HR regulation than vice versa, and with stronger respiratory influence (RESP → PEEG) on central activity than vice versa. This suggests that the central-cardiorespiratory process (closed-loop) is mainly focused on adapting the HR via the sinoatrial node than focusing on respiratory regulation. On the other hand, the feedback-loop from ANS to CNS is strongly dominated via respiratory activity. Significance: We demonstrated a considerably significantly different CCRN structure in SZO with a strong central influence on the cardiac system and a strong respiratory influence on the CNS. Moreover, this study provides a more in-depth understanding of the interplay of the central and autonomic regulatory network in healthy subjects and SZO patients.