C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.
C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.
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DOI：
10.1371/journal.pone.0147303
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kushiyama A
中科院分区：
文献类型：
--
作者：
Sonoda R;Tanaka K;Kikuchi T;Onishi Y;Takao T;Tahara T;Yoshida Y;Suzawa N;Kawazu S;Iwamoto Y;Kushiyama A
在这项研究中，我们调查胰岛素分泌和其他临床信息的措施如何影响2型糖尿病患者的长期血糖控制。在2012年10月至2014年6月期间，我们监测了202名糖尿病患者，他们因血糖控制以及糖尿病管理培训和教育而入住朝日生命基金会医院。我们在出院后6个月测量糖化血红蛋白（HbA 1c），以评估疾病管理。在单因素分析中，空腹血浆C肽免疫反应性（F-CPR）和合并尿CPR（U-CPR）与HbA 1c显著相关，而ΔCPR和C肽指数（CPI）则相反。这种关联与大多数其他患者变量无关。在探索性因素分析中，5个潜在因素，即胰岛素抵抗、年龄、性别差异、胰岛素分泌和血糖控制，代表了患者的特征。特别是，胰岛素分泌和抵抗强烈影响F-CPR，而胰岛素分泌影响U-CPR。总之，数据表明，在2型糖尿病患者中，F-CPR和U-CPR可以预测住院后6个月血糖控制的改善。
In this study, we investigate how measures of insulin secretion and other clinical information affect long-term glycemic control in patients with type 2 diabetes mellitus. Between October 2012 and June 2014, we monitored 202 diabetes patients who were admitted to the hospital of Asahi Life Foundation for glycemic control, as well as for training and education in diabetes management. We measured glycated hemoglobin (HbA1c) six months after discharge to assess disease management. In univariate analysis, fasting plasma C-peptide immunoreactivity (F-CPR) and pooled urine CPR (U-CPR) were significantly associated with HbA1c, in contrast to ΔCPR and C-peptide index (CPI). This association was strongly independent of most other patient variables. In exploratory factor analysis, five underlying factors, namely insulin resistance, aging, sex differences, insulin secretion, and glycemic control, represented patient characteristics. In particular, insulin secretion and resistance strongly influenced F-CPR, while insulin secretion affected U-CPR. In conclusion, the data indicate that among patients with type 2 diabetes mellitus, F-CPR and U-CPR may predict improved glycemic control six months after hospitalization.
影响因子：
4.1
作者：
Incalzi RA;Corsonello A;Pedone C;Corica F;Carosella L;Mazzei B;Perticone F;Carbonin P;Gruppo Italiano di Farmacovigilanza nell'Anziano
通讯作者：
Gruppo Italiano di Farmacovigilanza nell'Anziano