ETV6 gene rearrangements in invasive breast carcinoma
ETV6 gene rearrangements in invasive breast carcinoma
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DOI：
10.1002/gcc.20200
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发表时间：
2005-09-01
影响因子：
3.7
通讯作者：
Chaffanet, M
中科院分区：
文献类型：
--
作者：
Letessier, A;Ginestier, C;Chaffanet, M
ETV6/TEL基因编码一种转录因子，在几种类型的癌症中频繁重排。我们在包含632个肿瘤样本的组织芯片切片上，利用BAC探针的荧光原位杂交(FISH)技术，寻找浸润性乳腺癌中的ETV6重排。在这些样本中，有356个样本获得了足够质量的FISH筛选信号。5例(1例小叶、1例不典型分泌型、1例混合型、2例导管癌)出现ETV6重排。(C)2005年Wiley-Liss，Inc.
The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement. (c) 2005 Wiley-Liss, Inc.