Comparison of optimized single and multifield irradiation plans of antiproton, proton and carbon ion beams
Comparison of optimized single and multifield irradiation plans of antiproton, proton and carbon ion beams
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DOI：
10.1016/j.radonc.2010.02.026
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发表时间：
2010-04-01
影响因子：
5.7
通讯作者：
Petersen, Jorgen B.
中科院分区：
文献类型：
--
作者：
Bassler, Niels;Kantemiris, Ioannis;Petersen, Jorgen B.
背景和目的：反质子被认为是一种可能更好的放射治疗方法，因为反质子湮灭时释放的能量增强了布拉格峰，并在剂量中引入了高LET成分。方法：使用蒙特卡罗程序FLUKA生成质子、反质子和碳离子的深度剂量核。然后，我们根据ICRU针对不同射束模式的建议建立优化的虚拟治疗计划，然后使用FLUKA重新计算。根据这些计划产生的剂量-体积直方图可以用来比较不同的照射。结果：湮灭反质子在物理剂量和可能的生物剂量上的增强可以显著降低入射通道中的剂量，但代价是来自远程次级粒子的扩散的低剂量背景。结论：不同治疗方案的剂量-体积直方图显示，反质子有可能减少接受中到高剂量的正常组织的体积，但在低剂量区，反质子不如质子和碳离子。这将潜在用途限制在必须尽可能减少对正常组织的剂量的情况下。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。放射治疗与肿瘤学95(2010)87-93
Background and purpose: Antiprotons have been suggested as a possibly superior modality for radiotherapy, due to the energy released when antiprotons annihilate, which enhances the Bragg peak and introduces a high-LET component to the dose. However, concerns are expressed about the inferior lateral dose distribution caused by the annihilation products.Methods: We use the Monte Carlo code FLUKA to generate depth-dose kernels for protons, antiprotons, and carbon ions. Using these we then build virtual treatment plans optimized according to ICRU recommendations for the different beam modalities, which then are recalculated with FLUKA. Dose-volume histograms generated from these plans can be used to compare the different irradiations.Results: The enhancement in physical and possibly biological dose from annihilating antiprotons can significantly lower the dose in the entrance channel; but only at the expense of a diffuse low dose background from long-range secondary particles. Lateral dose distributions are improved using active beam delivery methods, instead of flat fields.Conclusions: Dose-volume histograms for different treatment scenarios show that antiprotons have the potential to reduce the volume of normal tissue receiving medium to high dose, however, in the low dose region antiprotons are inferior to both protons and carbon ions. This limits the potential usage to situations where dose to normal tissue must be reduced as much as possible. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 95 (2010) 87-93