Inflammasomes: a preclinical assessment of targeting in atherosclerosis.
Inflammasomes: a preclinical assessment of targeting in atherosclerosis.
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炎症性小体：动脉粥样硬化靶向的临床前评估。
DOI：
10.1080/14728222.2020.1795831
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发表时间：
2020-09
影响因子：
5.8
通讯作者：
Razani B
中科院分区：
文献类型：
--
作者：
Stitham J;Rodriguez-Velez A;Zhang X;Jeong SJ;Razani B
Inflammasomes are central to atherosclerotic vascular dysfunction with regulatory effects on inflammation, immune modulation, and lipid metabolism. The NLRP3 inflammasome is a critical catalyst for atherogenesis thus highlighting its importance in understanding the pathophysiology of atherosclerosis and for the identification of novel therapeutic targets and biomarkers for the treatment of cardiovascular disease. This review includes an overview of macrophage lipid metabolism and the role of NLRP3 inflammasome activity in cardiovascular inflammation and atherosclerosis. We highlight key activators, signal transducers and major regulatory components that are being considered as putative therapeutic targets for inhibition of NLRP3-mediated cardiovascular inflammation and atherosclerosis. NLRP3 inflammasome activity lies at the nexus between inflammation and cholesterol metabolism; it offers unique opportunities for understanding atherosclerotic pathophysiology and identifying novel modes of treatment. As such, a host of NLRP3 signaling cascade components have been identified as putative targets for drug development. We catalog these current discoveries in therapeutic targeting of the NLRP3 inflammasome and, utilizing the CANTOS trial as the translational (bench-to-bedside) archetype, we examine the complexities, challenges, and ultimate goals facing the field of atherosclerosis research.
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影响因子：
5.6
作者：
Antonov, Alexander S.;Antonova, Galina N.;Munn, David H.;Mivechi, Nahid;Lucas, Rudolf;Catravas, John D.;Verin, Alexander D.
通讯作者：
Verin, Alexander D.
DOI：
10.1161/atvbaha.117.310097
发表时间：
2017-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Baylis RA;Gomez D;Mallat Z;Pasterkamp G;Owens GK
通讯作者：
Owens GK
影响因子：
5.3
作者：
Bhaskar, Vinay;Yin, Johnny;Kantak, Seema S.
通讯作者：
Kantak, Seema S.
影响因子：
6
作者：
Antonov, AS;Kolodgie, FD;Gerrity, RG
通讯作者：
Gerrity, RG
影响因子：
24
作者：
Cai, Tianxi;Zhang, Yichi;Liao, Katherine P.
通讯作者：
Liao, Katherine P.