CORTICAL DYSPLASIA ASSOCIATED WITH MASSIVE ECTOPIA OF NEURONS AND GLIAL-CELLS WITHIN THE SUBARACHNOID SPACE
CORTICAL DYSPLASIA ASSOCIATED WITH MASSIVE ECTOPIA OF NEURONS AND GLIAL-CELLS WITHIN THE SUBARACHNOID SPACE
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DOI：
10.1007/bf00693774
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发表时间：
1987-01-01
影响因子：
12.7
通讯作者：
MATTHIAS, SC
中科院分区：
文献类型：
--
作者：
CHOI, BH;MATTHIAS, SC
对一名31天大的早产儿的大脑进行了详细的神经病理学研究，发现蛛网膜下腔内存在大量神经元和神经胶质细胞的异位。神经组织向蛛网膜下腔的挤压似乎是通过多个软脑膜-神经胶质桥发生的。这些部位的板层皮质模式也受到严重干扰。正常皮质和发育不良皮质的狭窄条带交替，与软膜-神经胶质间隙的存在或不存在直接相关。有丝分裂后神经元的迁移和迁移后神经元的最终定位似乎发生在高度特定和受限的径向路径中。我们的发现提示软脑膜-神经胶质屏障在控制神经元迁移中起重要作用，它的破坏可能导致蛛网膜下腔内神经元和神经胶质细胞异位的形成。强调了放射状胶质细胞、胶质细胞限制区和基底板在皮质神经发生中的重要作用。
A detailed neuropathological study of the brain of a 31-day-old premature newborn infant revealed the presence of massive ectopia of neurons and glial cells within the subarachnoid space. The extrusion of neural tissue into the subarachnoid space appeared to have taken place through multiple pial-glial bridges. The laminar cortical pattern was also severely disturbed at these sites. Narrow strips of normal and dysplastic cortex alternated in direct relationship to the presence or absence of the pial-glial gaps. Migration of postmitotic neurons and the final positioning of postmigratory neurons appear to take place within highly specified and restricted pathways entrained in a radial direction. Our findings suggest that the pial-glial barrier plays an important role in the control of neuronal migration, and that its disruption may lead to the development of neuronal and glial cell ectopias in the subarachnoid space. The crucial role played by radial glia, the glia limitans and the basal lamina during cortical neurogenesis is emphasized.