PROGESTERONE SYNTHESIS AND MYELIN FORMATION BY SCHWANN-CELLS
PROGESTERONE SYNTHESIS AND MYELIN FORMATION BY SCHWANN-CELLS
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DOI：
10.1126/science.7770777
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发表时间：
1995-06-09
期刊：
影响因子：
56.9
通讯作者：
BAULIEU, EE
中科院分区：
文献类型：
--
作者：
KOENIG, HL;SCHUMACHER, M;BAULIEU, EE
这里显示黄体酮是由周围神经中的施万细胞从孕烯醇酮产生的。雄性小鼠的坐骨神经冷冻后，轴突再生并变得有髓鞘。阻断黄体酮的局部合成或受体介导的作用会损害髓鞘再生。向病变部位施用黄体酮或其前体孕烯醇酮可增加髓鞘形成的程度。当向大鼠背根神经节培养物中添加黄体酮时，轴突的髓鞘形成也增加。这些观察结果表明局部产生的黄体酮在髓鞘形成中的作用，证明黄体酮不仅仅是一种性类固醇，并提出了一种促进髓鞘修复的新治疗方法。
Progesterone is shown here to be produced from pregnenolone by Schwann cells in peripheral nerves, After cryolesion of the sciatic nerve in male mice, axons regenerate and become myelinated. Blocking either the local synthesis or the receptor-mediated action of progesterone impaired remyelination. Administration of progesterone or its precursor, pregnenolone, to the lesion site increased the extent of myelin sheath formation. Myelination of axons was also increased when progesterone was added to cultures of rat dorsal root ganglia. These observations indicate a role for locally produced progesterone in myelination, demonstrate that progesterone is not simply a sex steroid, and suggest a new therapeutic approach to promote myelin repair.