Inertial particle deposition in a monkey nasal mold compared with that in human nasal replicas
Inertial particle deposition in a monkey nasal mold compared with that in human nasal replicas
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DOI：
10.1080/08958370500241270
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发表时间：
2005-12-15
影响因子：
2.1
通讯作者：
Wong, BA
中科院分区：
文献类型：
--
作者：
Kelly, JT;Asgharian, B;Wong, BA
鼻腔颗粒沉积信息用于空气颗粒污染物暴露风险评估和优化治疗气雾剂的输送。猴子通常用于评估吸入物质的治疗潜力，并在较小程度上评估吸入异生物质的毒性。然而，迄今为止，尚未报道过猴鼻气道中>1μm颗粒沉积效率的可靠测量结果。本研究的目的是测量猴子鼻腔气道复制品的沉积效率（>1μm），并通过将结果与最近报告的人类鼻腔复制品的类似测量结果进行比较，研究人类和猴子之间鼻腔沉积的潜在差异。猴鼻模型是一个亚克力模具，由 12 公斤重的雄性恒河猴死后鼻腔模型制成。对于 1 至 10 μm 之间的单分散气溶胶以及 2 至 7 lpm 之间的恒定吸气流速，测量了猴鼻模中的颗粒沉积。随着颗粒惯性的增加，总沉积效率从接近 0% 增加到 100%，并且由惯性冲击参数值唯一确定。根据基于最小横截面积的等效斯托克斯数进行比较，猴子复制品的沉积效率与人鼻复制品的沉积效率非常一致。这项研究的结果可以改进猴子到人类的外推模型以及对使用猴子进行的颗粒毒性和治疗气雾剂研究的数据的解释。
Information on nasal particle deposition is used in risk assessments for exposure to airborne particulate pollutants and for optimizing the delivery of therapeutic aerosols. Monkeys are commonly used to assess the therapeutic potential of inhaled substances and to a lesser extent the toxicity of inhaled xenobiotics. Yet no reliable measurements of the deposition efficiency of monkey nasal airways for particles >1 mu m have been reported to date. The goals of this study were to measure the deposition efficiency (>1 mu m) of a replica of monkey nasal airways and to investigate potential differences in nasal deposition between humans and monkeys by comparing results with similar measurements recently reported for human nasal replicas. The monkey nasal replica was an acrylic mold made from a postmortem cast of the nasal airways of a 12-kg, male rhesus monkey. Particle deposition in the monkey nasal mold was measured for monodisperse aerosols between 1 and 10 mu m and constant inspiratory flow rates between 2 and 7 lpm. Total deposition efficiency increased from nearly 0 to 100% with increasing particle inertia and was uniquely determined by values of an inertial impaction parameter. The deposition efficiencies of the monkey replica agreed well with those of human nasal replicas when compared according to equivalent Stokes numbers based on minimum cross-sectional area. Results from this study could improve monkey-to-human extrapolation models and interpretations of data from particle toxicity and therapeutic aerosol studies using monkeys.