The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo
The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo
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DOI：
10.1016/s0306-4522(00)00498-x
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发表时间：
2001-01-01
期刊：
影响因子：
3.3
通讯作者：
O'Mara, SM
中科院分区：
文献类型：
--
作者：
Commins, S;O'Neill, LAJ;O'Mara, SM
脂多糖来源于革兰氏阴性菌的细胞壁，是一种强效内毒素，可引起CNS中细胞因子的释放。我们研究了脂多糖对在体海马CA 1-海马下托通路突触传递和突触可塑性的影响。我们发现，脂多糖并不影响基线突触传递在这一途径，但它确实减少了成对脉冲易化的幅度，短期可塑性的一种形式，被认为主要是突触前起源。然后，我们研究了脂多糖和两种常见的模型之间的相互作用的记忆的生物学基础：高频刺激诱导的长时程增强和低频刺激诱导的突触传递的长时程抑制。我们发现脂多糖阻断高频刺激后的长时程增强，也诱导低频刺激后的突触传递增强。脂多糖阻断双脉冲易化选择性短rattler比较长的刺激间隔。因此，脂多糖对该通路中突触传递的影响因刺激频率和刺激时间的不同而不同，这些结果为脂多糖对海马可塑性的影响提供了新的认识。这一区域在学习和记忆中起着至关重要的作用。(C)2001年IBRO。出版社：Elsevier Science Ltd
Lipopolysaccharide is derived from the cell wall of gram-negative bacteria and is a potent endotoxin which causes the release of cytokines in the CNS. We examined the effect of lipopolysaccharide on synaptic transmission and synaptic plasticity in the hippocampal area CA1-subicular pathway in vivo. We found that lipopolysaccharide did not affect baseline synaptic transmission in this pathway; it did, however, reduce the magnitude of paired-pulse facilitation, a form of short-term plasticity thought to be primarily presynaptic in origin. We then examined the interaction between lipopolysaccharide and two common models for the biological basis of memory: high-frequency stimulation induced long-term potentiation and low frequency stimulation induced long-term depression of synaptic transmission. We found that lipopolysaccharide blocked long-term potentiation following high-frequency stimulation and also induced potentiation of synaptic transmission after low-frequency stimulation. Lipolysaccharide blocked paired-pulse facilitation selectively at short rattler than longer interstimulus intervals. Thus, lipopolysaccharide has different effects on synaptic transmission in this pathway depending on the frequency and length of stimulation.These results provide new insights into the action of lipopolysaccharide on various forms of plasticity in dir hippocampus. an area known to play a vital role in learning and memory. (C) 2001 IBRO. Published by Elsevier Science Ltd.