Radioactive isotope separation with 3D-printed flow-based device
Radioactive isotope separation with 3D-printed flow-based device
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DOI：
10.1007/s44211-022-00254-9
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发表时间：
2023-05-01
影响因子：
1.6
通讯作者：
Ohira，Shin-Ichi
中科院分区：
文献类型：
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作者：
Obata，Syohei;Sugo，Yumi;Ohira，Shin-Ichi
放射性同位素(RI)金属是一种新型的正电子发射断层显像剂，它是用回旋加速器对靶金属进行质子辐照而产生的。需要快速有效地将生成的金属RIS与目标金属分离。在本研究中，我们开发了一种3D打印流动装置来分离金属RIS和目标金属。根据形成常数的不同，选择性地形成乙二胺四乙酸(EDTA)络合物进行分离。RI金属选择性地形成EDTA络合物，从而改变其在溶液中的离子电荷。然后将溶液引入阳离子交换柱，对目标金属进行选择性吸附。将添加了络合剂和控制pH的溶液引入到所开发的系统中，在14分钟内自动分离了金属RI和目标金属。采用107pg L−167Ga-250mgL−1Zn2+的混合液，将RI67Ga从靶金属锌中分离出来。67Ga和锌的回收率分别为97%和100.00%。此外，系统中还集成了一个紫外线(UV)辐射反应器来分解EDTA络合物并回收GA3+离子。紫外线辐射回收GA3+的效果较好，回收率为87%。所开发的系统也成功地应用于分离锆和钇。因此，该方法和系统可用于分离其他金属和靶金属。
Radioactive isotope (RI) metals are a new type of tracer for positron emission tomography generated from the target metal by proton irradiation using a cyclotron. The generated metal RIs need to be separated from the target metal rapidly and effectively. In the present study, we developed a 3D-printed flow device to separate metal RIs from target metals. The separation was performed with selective formation of ethylenediaminetetraacetic acid (EDTA) complex based on the difference in formation constants. The RI metal selectively formed a EDTA complex, thus changing its ionic charge in solution. The solution was then introduced into a cation exchange column for selective adsorption of the target metal. The solution with added chelator and controlled pH was introduced into the developed system and automatically separated metal RI from target metals within 14 min. The separation method was applied to separate RI67Ga from target metal Zn using a mixture of 107 pg L−167Ga in 250 mg L−1Zn2+. The recoveries of67Ga and Zn were 97% and 100%, respectively. Furthermore, an ultraviolet (UV) radiation reactor was integrated into the system to decompose the EDTA complex and recover the Ga3+ion. Ga3+recovery by UV radiation was effective, 87%. The developed system was also successfully applied to the separation of Zr and Y. Therefore, the method and system can be applied to separate other metal RIs from target metals.Graphical abstract