Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?

Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?
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DOI:
10.1146/annurev-physiol-040122-081302
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发表时间:
2023-02-10
影响因子:
18.2
通讯作者:
--
中科院分区:
医学1区
文献类型:
--
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内部身体模型的生成及其持续更新在感觉运动控制中是必不可少的。虽然已知依赖于本体感觉反馈,但将这种感觉反馈转化为动态身体感受的潜在机制仍然知之甚少。然而,在本体感受回路元件(包括感觉受体)的遗传工具的开发方面取得的进展,正在开始提供新的和前所未有的杠杆作用,以解剖负责本体感受编码的中枢通路。同时,通过新兴的仿生神经机器接口技术获得的新数据揭示了有关动觉感觉反馈的相对重要性的线索,并深入了解了自然运动行为背后的功能性本体感受基质。
The generation of an internal body model and its continuous update is essential in sensorimotor control. Although known to rely on proprioceptive sensory feedback, the underlying mechanism that transforms this sensory feedback into a dynamic body percept remains poorly understood. However, advances in the development of genetic tools for proprioceptive circuit elements, including the sensory receptors, are beginning to offer new and unprecedented leverage to dissect the central pathways responsible for proprioceptive encoding. Simultaneously, new data derived through emerging bionic neural machine–interface technologies reveal clues regarding the relative importance of kinesthetic sensory feedback and insights into the functional proprioceptive substrates that underlie natural motor behaviors.
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