Quercetin suppresses glomerulosclerosis and TGF-β signaling in a rat model
Quercetin suppresses glomerulosclerosis and TGF-β signaling in a rat model
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DOI：
10.3892/mmr.2019.10118
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发表时间：
2019-06-01
影响因子：
3.4
通讯作者：
Yang, Jing
中科院分区：
文献类型：
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作者：
Liu, Yifan;Dai, Enlai;Yang, Jing
转化生长因子-β（TGF-β）信号通路是肾纤维化的重要调节通路，在肾小球硬化症中异常激活。槲皮素是一种常见的中草药，据报道可以抑制 TGF-β 信号通路的激活。在本研究中，构建了肾小球硬化大鼠模型，并用不同浓度的槲皮素治疗小鼠。采用免疫组化和蛋白质印迹法检测生化参数、病理指标和TGF-β信号通路相关蛋白的表达水平。结果表明，槲皮素可显着改善肾小球硬化大鼠的生理指标并改变TGF-β信号通路相关蛋白的表达水平。总之，槲皮素可以调节TGF-β信号通路并减缓肾小球硬化的进展。
The transforming growth factor-beta (TGF-beta) signaling pathway is an important regulatory pathway in renal fibrosis and is abnormally activated in glomerulosclerosis. Quercetin is a common Chinese herbal medicine and has been reported to inhibit TGF-beta signaling pathway activation. In the present study a glomerulosclerosis rat model was constructed and mice were treated with different concentrations of quercetin. Biochemical parameters, pathological indices and expression levels of TGF-beta signaling pathway-associated proteins were detected using immunohistochemistry and western blotting. It was demonstrated that quercetin significantly improved physiological indices and altered the expression levels of TGF-beta signaling pathway-associated proteins in rats with glomerulosclerosis. In conclusion, quercetin can regulate the TGF-beta signaling pathway and reduce the progression of glomerulosclerosis.