The impact and prospect of traumatic brain injury on olfactory function: a cross-sectional and prospective study
The impact and prospect of traumatic brain injury on olfactory function: a cross-sectional and prospective study
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DOI：
10.1007/s00405-013-2687-6
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发表时间：
2014-06-01
影响因子：
2.6
通讯作者：
Hummel, Thomas
中科院分区：
文献类型：
--
作者：
Gudziol, Volker;Hoenck, Irene;Hummel, Thomas
创伤性脑损伤（TBI）可导致嗅觉丧失。这项横断面和前瞻性研究的目的是确定110例创伤后3个月内TBI患者嗅觉丧失的患病率。在81名患者（“横断面”组）中，嗅觉功能可以使用经验证的“Sniffin' Sticks”测试来测量气味阈值和气味识别。此外，前瞻性变化的嗅觉功能进行了研究，在36例患者（“随访”组），通过一个有效的气味阈值，辨别和识别测试。与TBI IIA度和IIIA度的个体相比，TBI IA度的患者的嗅觉功能明显更好。在36%的患者中发现嗅觉功能的临床显著改善，最常见于损伤后的前6个月，中位随访时间为21个月。TBI IA程度通常对嗅觉没有重大影响。相比之下，患有TBI IIA度和IIIA度的患者表现出57%的嗅觉丧失。嗅觉恢复的机会在创伤后的前6个月内最高。
Traumatic brain injury (TBI) can cause olfactory loss. The aim of this cross-sectional and prospective study was to determine the prevalence of olfactory loss among 110 patients with TBI within 3 months after the trauma. In 81 patients ("cross-sectional"-group), olfactory function could be measured using the validated "Sniffin' Sticks" test for odor threshold and odor identification. In addition, the prospective change of olfactory function was studied in 36 patients ("follow-up"-group) by means of a validated odor threshold, discrimination and identification test. Olfactory function was significantly better in patients with TBI IA degrees compared to individuals with TBI IIA degrees and IIIA degrees. Clinically significant improvement of olfactory function was found in 36 % of the patients, most frequently during the first 6 months after the injury, in a median follow-up interval of 21 months. TBI IA degrees has in general no major effect on olfaction. In contrast, patients with TBI IIA degrees and IIIA degrees exhibit smell loss in 57 %. Chances for olfactory recovery were highest within the first 6 months after the trauma.