THE STEROID AND THYROID-HORMONE RECEPTOR SUPERFAMILY
THE STEROID AND THYROID-HORMONE RECEPTOR SUPERFAMILY
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DOI：
10.1126/science.3283939
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发表时间：
1988-05-13
期刊：
影响因子：
56.9
通讯作者：
EVANS, RM
中科院分区：
文献类型：
--
作者：
EVANS, RM
类固醇受体的分析对于理解转录调控的分子细节很重要，也有助于洞察单个交易因子如何影响细胞的特性和功能。这些研究导致了一个超家族调控蛋白的鉴定，其中包括甲状腺激素受体和脊椎动物形态生成物维甲酸。尽管动物使用复杂且往往不同的方式来控制它们的生理和发育，但在广泛物种中发现的受体相关分子表明，形态发生和动态平衡的潜在机制可能比之前预期的更加普遍。
Analyses of steroid receptors are important for understanding molecular details of transcriptional control, as well as providing insight as to how an individual transacting factor contributes to cell identity and function. These studies have led to the identification of a superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid. Although animals employ complex and often distinct ways to control their physiology and development, the discovery of receptor-related molecules in a wide range of species suggests that mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.