The signaling role for chloride in the bidirectional communication between neurons and astrocytes.
The signaling role for chloride in the bidirectional communication between neurons and astrocytes.
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DOI：
10.1016/j.neulet.2018.01.012
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发表时间：
2019-01-10
影响因子：
2.5
通讯作者：
Mongin AA
中科院分区：
文献类型：
--
作者：
Wilson CS;Mongin AA
众所周知，神经元网络中的电信号是由氯离子（Cl−）通过抑制性GABAA和甘氨酸受体调节的。在这里，我们讨论了Cl -通量和细胞内Cl -对CNS中其他形式的信息传递的假定贡献，即神经元和星形胶质细胞之间的双向通信。本文(i)总结了Cl -在细胞生理学中的一般功能，（ii）概述了神经元和星形胶质细胞中Cl -转运体和通道的分子特性和特性，（iii）分析了涉及Cl -调节神经胶质通讯的新研究。现有文献表明，神经元可以通过多种方式改变星形胶质细胞Cl -水平；通过(a)神经递质的释放和具有内在Cl -传导的胶质转运体的激活，(b)代谢受体驱动的电中性阳离子-Cl -共转运体NKCC1活性的变化，以及(c)胶质细胞体积的瞬时、活性依赖性变化，从而打开体积调节的Cl - /阴离子通道VRAC。反过来，星形胶质细胞被认为通过(a) vrac介导的抑制性胶质递质，GABA和牛磺酸的释放，打开神经元GABAA和甘氨酸受体/Cl -通道，或(b)胶质递质驱动的NKCC1刺激来改变神经元[Cl -]i。该领域最重要的最新进展是脑VRAC通道的分子组成和功能异质性的鉴定，以及一种新的细胞质[Cl−]传感器- Wnk家族蛋白激酶的发现。随着该领域的新工作，我们对Cl−在CNS信息处理中的作用的理解有望得到显著更新。
It is well known that the electrical signaling in neuronal networks is modulated by chloride (Cl−) fluxes via the inhibitory GABAA and glycine receptors. Here, we discuss the putative contribution of Cl− fluxes and intracellular Cl− to other forms of information transfer in the CNS, namely the bidirectional communication between neurons and astrocytes. The manuscript (i) summarizes the generic functions of Cl− in cellular physiology, (ii) recaps molecular identities and properties of Cl− transporters and channels in neurons and astrocytes, and (iii) analyzes emerging studies implicating Cl− in the modulation of neuroglial communication. The existing literature suggests that neurons can alter astrocytic Cl− levels in a number of ways; via (a) the release of neurotransmitters and activation of glial transporters that have intrinsic Cl− conductance, (b) the metabotropic receptor-driven changes in activity of the electroneutral cation-Cl− cotransporter NKCC1, and (c) transient, activity-dependent changes in glial cell volume which open the volume-regulated Cl−/anion channel VRAC. Reciprocally, astrocytes are thought to alter neuronal [Cl−]i through either (a) VRAC-mediated release of the inhibitory gliotransmitters, GABA and taurine, which open neuronal GABAA and glycine receptor/Cl− channels, or (b) the gliotransmitter-driven stimulation of NKCC1. The most important recent developments in this area are the identification of the molecular composition and functional heterogeneity of brain VRAC channels, and the discovery of a new cytosolic [Cl−] sensor – the Wnk family protein kinases. With new work in the field, our understanding of the role of Cl− in information processing within the CNS is expected to be significantly updated.
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影响因子：
6.2
作者：
Bekar, LK;Walz, W
通讯作者：
Walz, W
影响因子：
5.3
作者：
Blanz, Judith;Schweizer, Michaela;Jentsch, Thomas J.
通讯作者：
Jentsch, Thomas J.
DOI：
10.1152/physiologyonline.2000.15.6.309
发表时间：
2000-12-01
期刊：
NEWS IN PHYSIOLOGICAL SCIENCES
影响因子：
--
作者：
Delpire, E
通讯作者：
Delpire, E
WNK3激酶信号传导的抑制可减少脑损伤并加速中风后神经系统恢复。
影响因子：
8.3
作者：
Begum G;Yuan H;Kahle KT;Li L;Wang S;Shi Y;Shmukler BE;Yang SS;Lin SH;Alper SL;Sun D
通讯作者：
Sun D
DOI：
10.1085/jgp.81.1.53
发表时间：
1983-01
期刊：
The Journal of general physiology
影响因子：
--
作者：
Boron WF;Boulpaep EL
通讯作者：
Boulpaep EL